# US 2025/0082969 A1 · Methods and systems for treatment of systemic inflammatory disorders

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2025/0082969 A1
- Document ID: US20250082969A1
- Status: Published application
- Kind: A1
- Application number: 18/960,847
- Filed: 2024-11-26
- Published: 2025-03-13
- Earliest claimed: 2022-06-01
- Assignees: The Board of Trustees of the Leland Stanford Junior University
- Applicants: The Board of Trustees of The Leland Stanford Junior University
- Inventors: Nishant DOCTOR; Alexander SACKEIM
- Web page: https://patentgrep.com/patent/US20250082969A1

## CPC

- A61B 8/085: {for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules}
- A61N 7/00: Ultrasound therapy (lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 {; using ultrasound for introducing media into the body A61M37/0092})
- A61B 8/4227: {characterised by straps, belts, cuffs or braces}
- A61N 2007/0026: {Stimulation of nerve tissue}
- A61N 2007/0078: {with multiple treatment transducers}
- A61N 2007/0095: {by modifying an excitation signal}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

Medical energy devices, systems, and methods that allows for treatment of systemic inflammatory disorders through modulation of neural activity.

## Claims

### Claim 1

A method of applying an energy to one or more target nerves within a patient, the method comprising:
providing an energy device having a marker, where the marker is detachable from the energy device and where the energy device comprises an nesting area permitting coupling of the marker and the energy device;
determining an area on an exterior surface of the patient that allows passage of energy from the energy device through the exterior surface to the one or more target nerves;
affixing the marker on the area at the exterior surface;
coupling the energy device to the marker and to the patient such that the marker aligns the energy device towards the one or more target nerves;
applying energy from the energy device to the one or more target nerves through the exterior surface of the patient; and
detaching the energy device from the marker and the patient, where the marker remains affixed to the patient to permit subsequent attachment of the energy device to the marker and the patient and where the marker permits alignment of the energy device to the one or more target nerves.

### Claim 2 (depends on 1)

The method of claim 1, wherein determining the area on the exterior surface of the patient comprises noninvasive imaging of the patient to identify a target area containing the one or more target nerves.

### Claim 3 (depends on 1)

The method of claim 1, wherein the energy device comprises an ultrasound energy.

### Claim 4 (depends on 1)

The method of claim 1, wherein the marker comprises a sensor selected from the group consisting of a radio frequency identification (RFID) sensor and an electrical sensor.

### Claim 5 (depends on 1)

The method of claim 1, wherein the marker is configured to be magnetically coupled to the energy device.

### Claim 6 (depends on 1)

The method of claim 1, wherein the energy device is configured activate only when the marker is coupled to the energy device.

### Claim 7 (depends on 1)

The method of claim 1, wherein the one or more target nerves comprise a nerve selected from a group consisting of a superior ganglia of a vagus nerve, an inferior ganglia of the vagus nerve, a cervical vagus nerve, a thoracic vagus nerve, an abdominal vagus nerve, a celiac plexus nerve, a splenic nerve.

### Claim 8 (depends on 1)

The method of claim 1, where the energy device is configured to monitor a respiration cycle of the patient.

### Claim 9 (depends on 1)

The method of claim 1, where the energy device comprises one or more actuators to reposition the energy device in response to movement of the patient.

### Claim 10 (depends on 1)

The method of claim 1, where applying energy from the energy device comprises applying a series of energy treatments to stimulate the one or more target nerves and varying a dosing parameter of one or more of the series of energy treatments to prevent nerve adaption of the one or more target nerves.

### Claim 11 (depends on 10)

The method of claim 10, wherein varying the dosing parameter comprises altering a frequency of one or more of the series of energy treatments.

### Claim 12 (depends on 11)

The method of claim 11, wherein altering the frequency comprises altering the frequency in a fixed step rate or a random step rate.

### Claim 13 (depends on 10)

The method of claim 10, wherein varying the dosing parameter comprises altering frequency of one or more of the series of energy treatments.

### Claim 14

A method of performing a repeat therapy to treat one or more target nerves with energy, where a marker is affixed to a patient such that the marker is previously positioned on an exterior surface of the patient in alignment with the one or more target nerves within the patient, the method comprising:
coupling an energy device to the marker such that the marker aligns the energy device with the one or more target nerves;
applying energy from the energy device to the one or more target nerves through the exterior surface of the patient; and
detaching the energy device from the marker and the patient, where the marker remains affixed to the patient to permit subsequent attachment of the energy device to the marker and the patient and where the marker permits alignment of the energy device to the one or more target nerves.

### Claim 15 (depends on 14)

The method of claim 14, wherein the energy device comprises an ultrasound energy.

### Claim 16 (depends on 14)

The method of claim 14, wherein the marker comprises a sensor selected from the group consisting of a radio frequency identification (RFID) sensor and an electrical sensor.

### Claim 17 (depends on 14)

The method of claim 14, wherein the marker is configured to be magnetically coupled to the energy device.

### Claim 18 (depends on 14)

The method of claim 14, wherein the energy device is configured activate only when the marker is coupled to the energy device.

### Claim 19 (depends on 14)

The method of claim 14, wherein the one or more target nerves comprise a nerve selected from a group consisting of a superior ganglia of a vagus nerve, an inferior ganglia of the vagus nerve, a cervical vagus nerve, a thoracic vagus nerve, an abdominal vagus nerve, a celiac plexus nerve, and a splenic nerve.

### Claim 20 (depends on 14)

The method of claim 14, where the energy device is configured to monitor a respiration cycle of the patient.

### Claim at position 21

-25. (canceled)

### Claim 26

A system for providing a repeated therapy to an internal organ within a patient, the system comprising:
a marker configured to be affixed to an exterior of the patient; and
an energy device having an energy treatment portion and having a fastener configured to permit securing of the energy device to an exterior of the patient, the energy device further including a mating surface to couple the marker and the energy device, such that when the marker is affixed to the exterior of the patient the energy device can be coupled to the marker allowing for automatic alignment of the energy treatment portion to the internal organ from the exterior of the patient.

### Claim at position 23

-38. (canceled)