# US 2025/0082933 A1 · Detecting and treating disordered breathing > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2025/0082933 A1 - Document ID: US20250082933A1 - Status: Published application - Kind: A1 - Application number: 18/955,418 - Filed: 2024-11-21 - Published: 2025-03-13 - Earliest claimed: 2007-06-27 - Assignees: Zoll Respicardia, Inc. - Applicants: Zoll Respicardia, Inc. - Inventors: Mark Gelfand; Howard R. Levin; Andrew Halpert; Antonios Panteleon - Web page: https://patentgrep.com/patent/US20250082933A1 ## CPC - A61N 1/3601: {of respiratory organs} - A61B 5/0826: {Detecting or evaluating apnoea events (sleep apnoea A61B5/4818)} - A61B 5/4818: {Sleep apnoea} - A61N 1/3605: {Implantable neurostimulators for stimulating central or peripheral nerve system} - A61N 1/3611: {Respiration control (stimulating respiratory organs A61N1/3601)} - A61B 5/0205: Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition - A61B 5/0816: {Measuring devices for examining respiratory frequency (measuring frequency of electric signals G01R23/00)} - A61B 5/091: Measuring volume of inspired or expired gases, e.g. to determine lung capacity - A61B 5/113: occurring during breathing - A61B 5/4836: {Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence)} - A61N 1/0551: {Spinal or peripheral nerve electrodes} - A61N 1/36139: {with automatic adjustment} - A61N 1/36514: {controlled by a physiological quantity other than heart potential, e.g. blood pressure (controlled by two or more physical parameters A61N1/36585)} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A system for treating disordered breathing of a human being includes an implantable transvenous stimulation lead having at least one stimulation electrode and a sensor configured to detect activity level of the human being. The system includes an energy source, a pulse generator and circuitry, the circuitry operative to receive a signal indicative of the activity level of the human being from the sensor, wherein the circuitry is configured to cause the energy source and the pulse generator to deliver spaced apart stimulation signals to the at least one stimulation electrode while the activity level of the human being is sufficiently low to be indicative of sleep. Spaced apart stimulation pulses from the electrode are configured to extend a duration of a time of at least one breath being defined as the time from an onset of inhalation to the onset of inhalation of a successive breath. ## Claims ### Claim 1 A system for treating disordered breathing of a patient comprising: an implantable device configured to generate at least one stimulation signal and deliver the at least one stimulation signal to at least one target tissue via at least one implantable lead coupled to the implantable device; and at least one respiration sensor comprising at least one accelerometer, wherein the implantable device is configured to receive a signal indicative of respiration from the at least one accelerometer, and adjust an energy of the at least one stimulation signal based on the signal indicative of respiration from the at least one accelerometer, wherein each stimulation signal of the at least one stimulation signal is characterized by a duration and comprises a series of current pulses generated for the duration of each stimulation signal. ### Claim 2 (depends on 1) The system of claim 1, wherein the implantable device comprises an energy source. ### Claim 3 (depends on 1) The system of claim 1, wherein the at least one respiration sensor comprises an implantable sensor. ### Claim 4 (depends on 1) The system of claim 1, wherein the at least one respiration sensor comprises a sensor external to the patient. ### Claim 5 (depends on 1) The system of claim 1, wherein the at least one target tissue comprises a phrenic nerve. ### Claim 6 (depends on 1) The system of claim 1, wherein the at least one implantable lead comprises a transvenous lead. ### Claim 7 (depends on 1) The system of claim 1, wherein the implantable device is configured to analyze a respiratory rate of the patient based on the signal indicative of respiration and adjust the energy of the at least one stimulation signal based on the respiratory rate. ### Claim 8 (depends on 1) The system of claim 1, wherein the implantable device is configured to adjust the duration of each stimulation signal to adjust the energy of the at least one stimulation signal. ### Claim 9 (depends on 1) The system of claim 1, wherein the duration of each stimulation signal is a duration of at least one patient breath. ### Claim 10 (depends on 1) The system of claim 1, wherein the implantable device is configured to adjust a frequency of the series of current pulses to adjust the energy of the at least one stimulation signal. ### Claim 11 (depends on 10) The system of claim 10, wherein the frequency of the series of current pulses is approximately 20 Hz. ### Claim 12 (depends on 1) The system of claim 1, wherein the implantable device is configured to vary a current of the at least one stimulation signal to adjust the energy of the at least one stimulation signal. ### Claim 13 (depends on 12) The system of claim 12, wherein the implantable device is configured to vary the current of the at least one stimulation signal between a first current level and a second current level that is higher than the first current level during the duration of each stimulation signal. ### Claim 14 (depends on 13) The system of claim 13, wherein the implantable device is configured to gradually increase the current from the first current level to the second current level during the duration of the each stimulation signal. ### Claim 15 (depends on 14) The system of claim 14, wherein the current gradually rises for approximately 30% of the duration of each stimulation signal. ### Claim 16 (depends on 14) The system of claim 14, wherein the implantable device is configured to gradually decrease the current from the second current level to the first current level during the duration of the each stimulation signal. ### Claim 17 (depends on 16) The system of claim 16 wherein the current gradually rises for approximately 30% of the duration of the stimulation signal and gradually decreases for approximately 30% of the duration of each stimulation signal. ### Claim 18 (depends on 13) The system of claim 13, wherein the implantable device is configured to gradually decrease the current from the second current level to the first current level during the duration of each stimulation signal. ### Claim 19 (depends on 18) The system of claim 18, wherein the stimulation signal gradually decreases for approximately 30% of the duration of each stimulation signal. ### Claim 20 (depends on 13) The system of claim 13 wherein a range for a second current level is about double a range for the first current level. ### Claim 21 (depends on 20) The system of claim 20, wherein the range for the first current level is about 1-2 mA and the range for the second current level is about 2-4 mA. ### Claim 22 (depends on 1) The system of claim 1, wherein the signal indicative of respiration is indicative of an obstructive apnea, a central apnea, or a mixed apnea.