# US 2025/0082925 A1 · Subcutaneous transcranial cortical electrotherapy stimulation method and device

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- Number: US 2025/0082925 A1
- Document ID: US20250082925A1
- Status: Published application
- Kind: A1
- Application number: 18/566,284
- Filed: 2022-06-01
- Published: 2025-03-13
- Earliest claimed: 2021-06-01
- Assignees: Epic Neuro, Inc.
- Applicants: Epic Neuro, Inc.
- Inventors: James William PHILLIPS; Robert M. ABRAMS
- Web page: https://patentgrep.com/patent/US20250082925A1

## CPC

- A61B 5/293: Invasive
- A61N 1/0539: {Anchoring of brain electrode systems, e.g. within burr hole}
- A61B 5/686: {Permanently implanted devices, e.g. pacemakers, other stimulators, biochips (A61B5/6861 takes precedence)}
- A61N 1/0531: {Brain cortex electrodes}
- A61N 1/36139: {with automatic adjustment}
- A61N 1/3616: {Voltage density or current density}
- A61N 1/36082: {Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

Systems and methods are described, which provides electrical stimulation to a person, where a current flow path is between a first electrode disposed below a scalp of the subject and outside a cranial cavity of the subject to a second electrode disposed below the scalp and outside the cranial cavity, and further comprises directing the current flow path through the subject's skull and into the brain tissue.

## Claims

### Claim 1

A device for electrical stimulation of a subject's brain, the device comprising:
a first electrode adapted to be implanted under a scalp of the subject and outside the subject's cranial cavity;
a second electrode adapted to be implanted under the subject's scalp and outside the subject's cranial cavity;
insulating material surrounding a portion of the first electrode, the insulating material having an impedance higher than an impedance of a human skull; and
a current generator adapted to generate an electric current between the first electrode and the second electrode.

### Claim 2 (depends on 1)

The device of claim 1 further comprising insulating material surrounding a portion of the second electrode, the insulating material having an impedance higher than the impedance of a human skull.

### Claim 3 (depends on 1)

The device of claim 1 wherein the first electrode and the insulating material are disposed on a first side of the current generator.

### Claim 4 (depends on 3)

The device of claim 3 wherein the second electrode is disposed on the first side of the current generator.

### Claim 5 (depends on 3)

The device of claim 3 wherein the second electrode is disposed on a second side of the current generator.

### Claim 6 (depends on 1)

The device of claim 1 wherein the insulating material extends a uniform distance from a circumference of the first electrode.

### Claim 7 (depends on 1)

The device of claim 1 wherein the insulating material extends in non-uniform distances from a circumference of the first electrode.

### Claim 8 (depends on 1)

The device of claim 1 wherein the first electrode comprises a screw adapted to be screwed into the subject's skull.

### Claim 9

A method for providing electrical stimulation to brain tissue of a subject, the method comprising:
generating a current flow path between a first electrode disposed below a scalp of the subject and outside a cranial cavity of the subject to a second electrode disposed below the scalp and outside the cranial cavity; and
directing the current flow path through the subject's skull and into the brain tissue.

### Claim 10 (depends on 9)

The method of claim 9 wherein the directing step comprises resisting current flow between the first electrode and the second electrode outside of the skull with insulating material having an impedance higher than an impedance of the skull.

### Claim 11 (depends on 10)

The method of claim 10 wherein the insulating material surrounds a portion of the first electrode.

### Claim 12 (depends on 11)

The method of claim 11 wherein the insulating material surrounds a portion of the second electrode.

### Claim 13 (depends on 10)

The method of claim 10 wherein the method further comprises placing the insulating material against an outside surface of the skull between the first electrode and the second electrode.

### Claim 14 (depends on 9)

The method of claim 9 wherein the generating step comprises generating current with a current generator disposed between the scalp and the skull.

### Claim 15 (depends on 9)

The method of claim 9 further comprising screwing the first electrode into the skull.

### Claim 16 (depends on 9)

The method of claim 9 further comprising creating an opening through the skull to the cranial cavity adjacent the first electrode or the second electrode.

### Claim 17

A method for obtaining an EEG of a subject's brain, the method comprising:
sensing an electroencephelography signal from a first electrode disposed below a scalp of the subject and outside a cranial cavity of the subject and a second electrode disposed below the scalp and outside the cranial cavity; and
recording the electroencephelography signal.

### Claim 18 (depends on 17)

The method of claim 17 wherein at least a portion of the first electrode and/or the second electrode is surrounded by an insulating material.