Combination wearable and stationary dialysis system with ultrafiltrate module
OwnerVictor Gurainventor
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Abstract
The present disclosure includes systems and methods for hemodialysis, such as including a first dialysis module and an auxiliary module detachably connectable to the first dialysis module. The first dialysis module can include a dialyzer, a blood circuit, a dialysate circuit, and a sorbent. The auxiliary module can include an ultrafiltrate collector operably couplable to the dialysate circuit for removing excess fluid therefrom.
Claims21
1-20. (canceled)
A system for regenerating dialysate, the system comprising:
- (i) an ambulatory module comprising:
- a blood circuit configured to process a patient's blood;
- a dialyzer configured to diffuse toxins from the blood circuit to the dialysate;
- a pulsatile pump;
- a first dialysate circuit configured to circulate the dialysate through the ambulatory module;
- an ambulatory module-located cartridge in fluid connection with the first dialysate circuit, wherein the ambulatory module-located cartridge is configured to remove toxins from the dialysate;
- and
- a detachable ultrafiltrate collector;
- and
- (ii) a stationary module comprising:
- a second dialysate circuit configured to circulate the dialysate through the stationary module;
- a plurality of cartridges in fluid connection with each other and the dialysate circuit, wherein the plurality of cartridges are aligned along an axis, wherein (1) a first cartridge of the plurality of cartridges comprises a sorbent configured to remove uremic metabolites and metals and (2) one or more other cartridges of the plurality of cartridges comprises urease;
- at least one bubble filter positioned along the dialysate circuit after the urease cartridge;
- and
- at least one ammonia sensor positioned along the dialysate circuit after the plurality of cartridges;
- and
- wherein the ambulatory module and the stationary module are independently or jointly operable for dialysate regeneration.
The system of claim 1, wherein the pulsatile pump is configured to create a pulsatile flow where a blood pulse and a dialysate pulse are out of phase.
The system of claim 1, wherein the detachable ultrafiltrate collector further comprises a pump and an outlet port to remove ultrafiltrate.
The system of claim 1, wherein the sorbent configured to remove uremic metabolite and metals is activated carbon.
The system of claim 1, wherein the last of the plurality of cartridges is configured to remove ammonia from the dialysate.
The system of claim 1, wherein each of the ambulatory module-located and stationary cartridges comprise a single sorbent.
The system of claim 1, wherein each of the ambulatory module-located and stationary cartridges comprise a plurality of sorbents.
The system of claim 1, wherein the ambulatory module-located cartridge composition module is the same as at least one of the plurality of cartridges of the stationary module.
The system of claim 1, wherein the dialysate flows directly between the plurality of cartridges along the axis.
The system of claim 1, wherein a bubble filter of the at least one bubble filter is positioned along the second dialysate circuit after each cartridge of the plurality of cartridges that produce gas.
The system of claim 1, wherein an ammonia sensor of the at least one ammonia sensor is positioned along the second dialysate circuit after each cartridge of the plurality of cartridges.
The system of claim 1, wherein the ambulatory module further comprises a portable power source.
The system of claim 1, wherein the stationary module further comprises at least one electrolyte module configured to facilitate electrolyte homeostasis.
The system of claim 1, wherein the ambulatory module and the stationary module are connected along a dialysate inlet and a dialysate outlet.
The system of claim 1, wherein the ambulatory module and stationary module are configured to operate over a 24 hour cycle.
The system of claim 1, wherein the ambulatory module is configured to be worn by the patient.
Dependencies are inferred from the claim text.