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AssigneesUniversity of Central Florida Research Foundation, Inc., Sanford Burnham Prebys Medical Discovery Institute
InventorsSudipta SEAL, Soumen DAS, William SELF, Dwight TOWLER
Estimating the term…
An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coating. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.
A method of conducting an orthopedic procedure, the method comprising
A method of reducing osteolysis in a subject in need, the method comprising administering nanoceria comprising catalase activity, superoxide dismutase activity, or both, to an injury, defect or disease site of bone in the subject.
Dependencies are inferred from the claim text.