Listeria Variants and Methods of Use Thereof

Abstract

The present disclosure provides variant Listeria bacteria that lack functional ribC and ribF genes. Also provided are methods of making and using the variant Listeria bacteria, e.g., as vectors, vaccines, and therapeutics. The present disclosure provides variant Listeria bacteria that provide for production of a Mucosal-Associated Invariant T (MAIT) cell ligand in vivo. Also provided are methods of making and using the variant Listeria bacteria, e.g., to stimulate and expand the number of MAIT cells in an individual.

Dependencies are inferred from the claim text.