m6A mRNA MODIFICATION IN CANCER TREATMENT
AssigneeCity of Hope
InventorsYanhong SHI, Qi CUI
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Abstract
Disclosed herein are methods of treating cancer by increasing mRNA m6A methylation level and/or decreasing mRNA m6A demethylation in cancer stem cells. The methods entail administering an effective amount of one or more therapeutic agents to the subject. The therapeutic agents include an agent that induces overexpression of METTL3, an agent that induces overexpression of METTL14, an agent that inhibits FTO, an agent that inhibits ALKBH5, and an agent that inhibits TLX. Also disclosed are pharmaceutical compositions for treating cancer, which compositions include one or more such therapeutic agents.
Claims22
A method for treating a subject suffering from a cancer comprising contacting a cancer stem cell with an FTO inhibitor, wherein the FTO inhibitor increases the mRNA methylation level in the cancer stem cells of the subject.
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A pharmaceutical composition for treating cancer, comprising one or more therapeutic agents that inhibit FTO.
Dependencies are inferred from the claim text.