Compositions and methods for enhancing cardiomyocyte transplant engraftment
AssigneesUniversity of Washington, International Centre for Genetic Engineering and Biotechnology (Icgeb)
InventorsCharles E. MURRY, Mauro GIACCA, Francesca BORTOLOTTI, Hiroshi TSUCHIDA
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Abstract
Described herein are compositions and methods related to enhancing cardiomyocyte transplant engraftment and methods of administering a transplant composition.
Claims48
A composition comprising cardiomyocytes in admixture with an isolated polypeptide selected from the group consisting of:
- the polypeptides listed in Table 1.
A composition comprising cardiomyocytes in admixture with two or more isolated polypeptides selected from the group consisting of:
- the polypeptides listed in Table 1.
A composition comprising cardiomyocytes that have been contacted with an isolated polypeptide selected from the group consisting of:
- the polypeptides listed in Table 1.
A composition comprising cardiomyocytes that have been contacted with two or more isolated polypeptides selected from the group consisting of:
- the polypeptides listed in Table 1.
A composition comprising cardiomyocytes and a nucleic acid construct encoding a polypeptide selected from the group consisting of:
- the polypeptides listed in Table 1.
A composition comprising cardiomyocytes and one or more nucleic acid constructs encoding two or more polypeptides selected from the group consisting of:
- the polypeptides listed in Table 1.
A composition comprising cardiomyocytes in admixture with an isolated metabolic factor polypeptide that promotes transplant engraftment of the cardiomyocytes, or with a nucleic acid construct that encodes such a factor.
A composition comprising cardiomyocytes in admixture with an isolated vascular remodeling, extracellular matrix, proteoglycan or cell adhesion polypeptide that promotes transplant engraftment of the cardiomyocytes, or with a nucleic acid construct that encodes such a factor.
A composition comprising cardiomyocytes in admixture with an isolated canonical Wnt pathway polypeptide.
A composition comprising cardiomyocytes that have been contacted with an isolated canonical Wnt pathway polypeptide.
A composition comprising cardiomyocytes in admixture with an isolated serine protease polypeptide.
A composition comprising cardiomyocytes that have been contacted with an isolated serine protease polypeptide.
A composition comprising cardiomyocytes in admixture with an isolated serine protease inhibitor polypeptide.
A composition comprising cardiomyocytes that have been contacted with an isolated serine protease inhibitor polypeptide.
A composition comprising cardiomyocytes in admixture with an isolated signaling polypeptide of the interleukin family, interferon signaling family, or chemokine family.
A composition comprising cardiomyocytes that have been contacted with an isolated signaling polypeptide of the interleukin family, interferon signaling family, or chemokine family.
A composition comprising cardiomyocytes in admixture with an isolated TLR binding polypeptide, a lipocalin polypeptide or a secretaglobin polypeptide.
A composition comprising cardiomyocytes that have been contacted with an isolated TLR binding polypeptide, a lipocalin polypeptide or a secretaglobin polypeptide.
A method of enhancing cardiomyocyte transplant engraftment, the method comprising contacting a cardiomyocyte population with a polypeptide selected from the group consisting of the polypeptides listed in Table 1, and transplanting the cardiomyocyte population to cardiac tissue.
A method of enhancing cardiomyocyte transplant engraftment, the method comprising contacting a cardiomyocyte population with a nucleic acid that encodes a polypeptide selected from the group consisting of the polypeptides listed in Table 1, and transplanting the cardiomyocyte population to cardiac tissue.
A method of enhancing cardiomyocyte transplant engraftment, the method comprising contacting a cardiomyocyte population with a vector that encodes a polypeptide selected from the group consisting of the polypeptides listed in Table 1, and transplanting the cardiomyocyte population to cardiac tissue.
Dependencies are inferred from the claim text.