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US 2025/0082672 A1Published application
Metal (hydr) oxide composite comprising poorly soluble drug, method for manufacturing same, and pharmaceutical composition comprising same
AssigneesWebiotree Co., Ltd., Cnpharm Co., Ltd.
InventorsHo Jun KIM, Geun Woo JIN, Ki Yeok KIM
Life of this patent
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Abstract
The present invention relates to a metal (hydr)oxide composite comprising a poorly soluble drug, a method for manufacturing same, and a pharmaceutical composition comprising same.
Claims13
A metal (hydr)oxide composite comprising:
- a metal (hydr)oxide;
- and a compound comprising at least one or more hydroxyl groups in the compound or a salt thereof,
- wherein the metal (hydr)oxide is one or more selected from the compounds represented by the following Chemical Formulas 3 to 5:
- [(M2+(1−x)M3+x(OH)2)((An−)z)]yH2O [Chemical Formula 3]
- (in Chemical Formula 3,
- M2+ is a divalent metal cation selected from the group consisting of Mg2+, Ni2+, Cu2+, Co2+, and Zn2+,
- M3+ is a trivalent metal cation selected from the group consisting of Al3+, Fe3+, V3+, Ti3+, Mn3+, and Ga3+,
- x is a number having a range of greater than 0 and less than or equal to 0.5,
- A is an anion selected from the group consisting of CO32−, NO3−, Br−, Cl−, SO42−, HPO42−, and F−,
- n is a charge number of the anion A,
- n is a number having a range of 0.5 or more and 2 or less,
- z is a number having a range of 0 or more and 1 or less, and
- y is a positive number greater than 0.),
- [(M2+(OH)2−x)((An−)z)]yH2O [Chemical Formula 4]
- (in Chemical Formula 4,
- M2+ is a divalent metal cation selected from the group consisting of Mg2+, Ni2+, Cu2+, Co2+, and Zn2+,
- x is a number having a range of 0 or more and 0.4 or less,
- A is an anion selected from the group consisting of CO32−, NO3−, Br−, Cl−, SO42−, HPO42−, and F−,
- n is a charge number of anion A,
- n is a number having a range of 0 or more and 2 or less,
- z is a number having a range of 0 or more and 1 or less, and
- y is a positive number greater than 0.), and
- [(M2+(O)2−x)((An−)z)]yH2O [Chemical Formula 5]
- (in Chemical Formula 5,
- M2+ is Mg2+, Ni2+, Cu2+, or Zn2+,
- x is a number of 1 or more and less than 2,
- A is an anion selected from the group consisting of CO32−, NO3−, Br−, Cl−, SO42−, HPO42−, and F−,
- n is a charge number of the anion A,
- n is a number having a range of 0 or more and 2 or less,
- z is a number having a range of 0 or more and 1 or less, and
- y is a positive number greater than 0.)
28 more elements
A pharmaceutical composition comprising:
- a metal (hydr)oxide;
- a compound comprising at least one or more hydroxyl groups in the compound or a salt thereof;
- and an additive,
- wherein the metal (hydr)oxide is one or more selected from the compounds represented by the following Chemical Formulas 3 to 5:
- [(M2+(1−x)M3+x(OH)2)((An−)z)]yH2O [Chemical Formula 3]
- (in Chemical Formula 3,
- M2+ is a divalent metal cation selected from the group consisting of Mg2+, Ni2+, Cu2+, Co2+, and Zn2+,
- M3+ is a trivalent metal cation selected from the group consisting of Al3+, Fe3+, V3+, Ti3+, Mn3+, and Ga3+,
- x is a number having a range of greater than 0 and less than or equal to 0.5,
- A is an anion selected from the group consisting of CO32−, NO3−, Br−, Cl−, SO42−, HPO42−, and F−,
- n is a charge number of the anion A,
- n is a number having a range of 0.5 or more and 2 or less,
- z is a number having a range of 0 or more and 1 or less, and
- y is a positive number greater than 0.),
- [(M2+(OH)2−x)((An−)z)]yH2O [Chemical Formula 4]
- (in Chemical Formula 4,
- M2+ is a divalent metal cation selected from the group consisting of Mg2+, Ni2+, Cu2+, Co2+, and Zn2+,
- x is a number having a range of 0 or more and 0.4 or less,
- A is an anion selected from the group consisting of CO32−, NO3−, Br−, Cl−, SO42−, HPO42−, and F−,
- n is a charge number of anion A,
- n is a number having a range of 0 or more and 2or less,
- z is a number having a range of 0 or more and 1or less, and
- y is a positive number greater than 0.), and
- [(M2+(O)2−x)((An−)z)]yH2O [Chemical Formula 5]
- (in Chemical Formula 5,
- M2+ is Mg2+, Ni2+, Cu2+, or Zn2+,
- x is a number of 1 or more and less than 2,
- A is an anion selected from the group consisting of CO32−, NO3−, Br−, Cl−, SO42−, HPO42−, and F−,
- n is a charge number of the anion A,
- n is a number having a range of 0 or more and 2 or less,
- z is a number having a range of 0 or more and 1 or less, and
- y is a positive number greater than 0.)
29 more elements
Dependencies are inferred from the claim text.