# US 2025/0082256 A1 · Systems, devices, and methods for electrophysiological recording from the eye

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- Number: US 2025/0082256 A1
- Document ID: US20250082256A1
- Status: Published application
- Kind: A1
- Application number: 18/883,376
- Filed: 2024-09-12
- Published: 2025-03-13
- Earliest claimed: 2023-09-12
- Assignees: Retmap, Inc.
- Applicants: Retmap, Inc.
- Inventors: John R. Hetling
- Web page: https://patentgrep.com/patent/US20250082256A1

## CPC

- A61B 5/398: Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
- A61B 5/251: Means for maintaining electrode contact with the body
- A61B 5/26: maintaining contact between the body and the electrodes by the action of the subjects, e.g. by placing the body on the electrodes or by grasping the electrodes
- A61B 5/297: for electrooculography [EOG]: for electroretinography [ERG]
- A61B 5/6821: {Eye}
- A61B 2562/0209: Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
- A61B 2562/16: Details of sensor housings or probes; Details of structural supports for sensors (A61B2560/0462 takes precedence)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

Systems, devices, and methods for electrophysiological recording from the eye are disclosed herein. An electroretinography device can detect a biopotential signal from an eye of a subject and transmit the same to a processor. Embodiments of the present technology include one or more features directed to improving the use and operability of an electroretinography device. For example, the device can include features for (i) inhibiting multiple devices from adhering or sticking to one another or a different object and (ii) providing tactile feedback to users to help distinguish one side of the device from the other.

## Claims

### Claim 1

An electroretinography device, comprising:
an ocular member configured to detect a biopotential signal from an eye of a subject, the ocular member including:
a proximal portion comprising a proximal outer surface extending radially inward along a distal direction, a proximal inner surface opposite the outer surface, and a proximal end surface extending between the proximal inner surface and the proximal outer surface, wherein, when the ocular member is disposed over the eye, the proximal inner surface is disposed over an anterior surface of the eye and the proximal outer surface is positioned adjacent an eyelid of the subject; and
a distal portion coupled to the proximal portion, wherein the distal portion comprises a distal outer surface extending radially outward in the distal direction, a distal inner surface opposite the distal outer surface and defining a distal recess, and a distal end surface extending between the distal inner surface and the distal outer surface,
wherein at least one of the proximal portion or the distal portion includes an interface feature configured to decrease contact area with another object;
a conductive element in an annular channel of the proximal portion; and
a signal relay operatively connected to the conductive element and configured to transmit the biopotential signal from the conductive element to a signal processor.

### Claim 2 (depends on 1)

The device of claim 1, wherein the interface feature comprises at least one bump positioned on the distal end surface.

### Claim 3 (depends on 1)

The device of claim 1, wherein the interface feature comprises at least one semi-spherical bump positioned on the distal end surface.

### Claim 4 (depends on 1)

The device of claim 1, wherein the interface feature comprises at least five bumps spaced apart along the distal end surface.

### Claim 5 (depends on 1)

The device of claim 1, wherein the interface feature comprises a plurality of cutouts or scallops along the proximal end surface.

### Claim 6 (depends on 1)

The device of claim 1, wherein the interface feature comprises a plurality of semi-circular cutouts or scallops along the proximal end surface.

### Claim 7 (depends on 1)

The device of claim 1, wherein the interface feature comprises a plurality of cutouts or scallops along the distal end surface.

### Claim 8 (depends on 1)

The device of claim 1, wherein the distal end surface extends at an angle relative to the distal direction.

### Claim 9

An electroretinography device, comprising:
a proximal portion comprising a proximal outer surface extending radially inward along a distal direction, a proximal inner surface opposite the outer surface, and a proximal end surface extending between the proximal inner surface and the proximal outer surface, wherein, when the proximal portion is disposed over an eye of subject, the proximal inner surface is disposed over an anterior surface of the eye and the proximal outer surface is positioned adjacent an eyelid of the subject; and
a distal portion coupled to the proximal portion, wherein the distal portion comprises a distal outer surface, a distal inner surface opposite the distal outer surface and defining a distal recess, and a distal end surface extending between the distal inner surface and the distal outer surface, wherein the distal portion includes an interface feature configured to decrease contact area with another object adjacent to the distal portion.

### Claim 10 (depends on 9)

The device of claim 9, wherein, due at least to the interface feature, the distal end surface is not planar.

### Claim 11 (depends on 9)

The device of claim 9, wherein the interface feature comprises a plurality of bumps positioned on the distal end surface, wherein the bumps are configured to contact the object adjacent to the distal portion such that the distal end portion does not contact the object.

### Claim 12 (depends on 9)

The device of claim 9, wherein the interface feature has a cross-sectional dimension between 1-5 millimeters.

### Claim 13 (depends on 9)

The device of claim 9, wherein the interface feature comprises a plurality of bumps positioned on the distal end surface, wherein adjacent ones of the bumps are equally spaced apart along the distal end surface.

### Claim 14 (depends on 9)

The device of claim 9, wherein the interface feature comprises a plurality of identically shaped and sized bumps positioned on the distal end surface.

### Claim 15 (depends on 9)

The device of claim 9, wherein the interface feature comprises a plurality of bumps positioned on the distal end surface, wherein at least two of the bumps are differently shaped or sized.

### Claim 16

An electroretinography device, comprising:
a proximal portion comprising a proximal outer surface extending radially inward along a distal direction, a proximal inner surface opposite the outer surface, and a proximal end surface extending between the proximal inner surface and the proximal outer surface, wherein, when the proximal portion is disposed over an eye of a subject, the proximal inner surface is disposed over an anterior surface of the eye and the proximal outer surface is positioned adjacent an eyelid of the subject; and
a distal portion coupled to the proximal portion, wherein the distal portion comprises a distal outer surface, a distal inner surface opposite the distal outer surface and defining a distal recess, and a distal end surface extending between the distal inner surface and the distal outer surface, wherein the proximal portion includes an interface feature configured to decrease contact area with another object adjacent to the proximal portion.

### Claim 17 (depends on 16)

The device of claim 16, wherein, due to the interface feature, the proximal end surface is not planar.

### Claim 18 (depends on 16)

The device of claim 16, wherein the interface features comprises a plurality of cutouts or scallops along the proximal end surface, wherein the cutouts or scallops are configured to not contact the object adjacent to the proximal portion.

### Claim 19 (depends on 16)

The device of claim 16, wherein the interface feature has a cross-sectional dimension between 1-5 millimeters.

### Claim 20 (depends on 16)

The device of claim 16, wherein the interface feature comprises a plurality of cutouts or scallops along the proximal end surface, wherein adjacent ones of the cutouts or scallops are equally spaced apart along the proximal end surface.

### Claim 21 (depends on 16)

The device of claim 16, wherein the interface feature comprises a plurality of identically shaped and sized cutouts or scallops along the proximal end surface.

### Claim 22 (depends on 16)

The device of claim 16, wherein the interface feature comprises a plurality of cutouts or scallops along the proximal end surface, wherein at least two of the cutouts or scallops are differently shaped or sized.
