# US 2025/0082255 A1 · Systems, devices, and methods for electrophysiological recording from the eye > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2025/0082255 A1 - Document ID: US20250082255A1 - Status: Published application - Kind: A1 - Application number: 18/883,279 - Filed: 2024-09-12 - Published: 2025-03-13 - Earliest claimed: 2023-09-12 - Assignees: Retmap, Inc. - Applicants: Retmap, Inc. - Inventors: John R. Hetling - Web page: https://patentgrep.com/patent/US20250082255A1 ## CPC - A61B 5/398: Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG] - A61B 5/251: Means for maintaining electrode contact with the body - A61B 5/26: maintaining contact between the body and the electrodes by the action of the subjects, e.g. by placing the body on the electrodes or by grasping the electrodes - A61B 5/297: for electrooculography [EOG]: for electroretinography [ERG] - A61B 5/6821: {Eye} - A61B 2562/0209: Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053 - A61B 2562/16: Details of sensor housings or probes; Details of structural supports for sensors (A61B2560/0462 takes precedence) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Systems, devices, and methods for electrophysiological recording from the eye are disclosed herein. An electroretinography device can detect a biopotential signal from an eye of a subject and transmit the same to a processor. Embodiments of the present technology include one or more features directed to improving the use and operability of an electroretinography device. For example, the device can include features for (i) improving the quality of light stimulus delivered to the eye or (ii) providing a better fit around the eye or a contact lens worn on the eye. These features can account for anatomical differences between different subjects by either masking or accommodating such differences. ## Claims ### Claim 1 An electroretinography device configured to detect a biopotential signal from an eye of a subject, comprising: an ocular member including: a proximal portion comprising a proximal outer surface extending radially inward along a distal direction and a proximal inner surface opposite the outer surface, wherein, when the ocular member is disposed over the eye, the proximal inner surface is disposed over an anterior surface of the eye and the proximal outer surface is positioned adjacent an eyelid of the subject; and a distal portion coupled to the proximal portion, wherein the distal portion comprises a distal outer surface extending radially outward in the distal direction, and a distal inner surface opposite the distal outer surface and defining at least in part a distal recess, wherein at least a portion the distal inner surface is roughened or non-smooth; a conductive element in an annular channel of the proximal portion; and a signal relay operatively connected to the conductive element and configured to transmit the biopotential signal from the conductive element to a signal processor. ### Claim 2 (depends on 1) The device of claim 1, wherein an entirety of the distal inner surface is roughened or non-smooth. ### Claim 3 (depends on 1) The device of claim 1, wherein only a portion of the proximal inner surface is roughened or non-smooth. ### Claim 4 (depends on 1) The device of claim 1, wherein: the proximal inner surface includes (i) a cornea portion and (ii) a sclera portion extending radially around the cornea portion, the sclera portion has a first cross-sectional dimension and the cornea portion has a second cross-sectional dimension smaller than the first cross-sectional dimension, the sclera portion is roughened or non-smooth, and the cornea portion comprises a smooth texture. ### Claim 5 (depends on 1) The device of claim 1, wherein the portion of the distal inner surface that is roughened or non-smooth is (i) an uneven surface and comprises a plurality of protrusions from a base surface, and (ii) configured to provide a light scattering effect to the eye upon a light stimulus being delivered to the device. ### Claim 6 (depends on 1) The device of claim 1, wherein the portion of the distal inner surface that is roughened or non-smooth is created via etching or spattering silicone. ### Claim 7 (depends on 1) The device of claim 1, further comprising a film positioned at the distal recess, wherein the film has a concave shape configured to conform to at least a portion of a cornea of the eye, wherein an intermediate portion of the film has a first transparency, and wherein a peripheral portion of the film has a second transparency less transparent than the first transparency. ### Claim 8 An electroretinography device, comprising: an ocular member configured to detect a biopotential signal from an eye of a subject, the ocular member including: a proximal portion comprising a proximal outer surface extending radially inward along a distal direction and a proximal inner surface opposite the proximal outer surface, wherein, when the ocular member is disposed over the eye, the proximal inner surface is disposed over an anterior surface of the eye and the proximal outer surface is positioned adjacent an eyelid of the subject; a distal portion coupled to the proximal portion, wherein the distal portion comprises a distal outer surface extending radially outward in the distal direction and a distal inner surface opposite the distal outer surface and defining a distal recess; and a film positioned at the distal recess, wherein the film has a concave shape configured to conform to at least a portion of a cornea of the eye, wherein an intermediate portion of the film has a first transparency, and wherein a peripheral portion of the film has a second transparency less transparent than the first transparency; a conductive element in a channel of the proximal portion; and a signal relay operatively connected to the conductive element and configured to transmit the biopotential signal from the conductive element to a signal processor. ### Claim 9 (depends on 8) The device of claim 8, wherein the intermediate portion of the film is transparent and/or comprises a transparent material, and wherein the peripheral portion of the film is opaque and/or comprises an opaque material. ### Claim 10 (depends on 8) The device of claim 8, wherein at least some of the distal portion is opaque and/or comprises an opaque material. ### Claim 11 (depends on 8) The device of claim 8, wherein the ocular member excluding the intermediate portion of the film comprises an opaque material. ### Claim 12 (depends on 8) The device of claim 8, wherein an entirety of the proximal portion comprises an opaque material. ### Claim 13 (depends on 8) The device of claim 8, wherein the peripheral portion of the film having the second transparency is configured to block at least some of a light stimulus such that the light stimulus reaches the eye primarily through the intermediate portion of the film having the first transparency. ### Claim 14 An electroretinography device, comprising: an ocular member configured to detect a biopotential signal from an eye of a subject, the ocular member including: a proximal portion comprising a proximal outer surface extending radially inward along a distal direction and a proximal inner surface opposite the proximal outer surface, wherein, when the ocular member is disposed over the eye, the proximal inner surface is disposed over an anterior surface of the eye and the proximal outer surface is positioned adjacent an eyelid of the subject; and a distal portion coupled to the proximal portion, wherein the distal portion comprises a distal outer surface and a distal inner surface opposite the distal outer surface and defining at least in part a distal recess, wherein the recess includes an opening extending through the ocular member in the distal direction; a conductive element in an annular channel of the proximal portion; and a signal relay operatively connected to the conductive element and configured to transmit the biopotential signal from the conductive element to a signal processor. ### Claim 15 (depends on 14) The device of claim 14, further comprising a lens structure having a curvature that is complementary to a curvature of at least a portion of a cornea of the eye. ### Claim 16 (depends on 14) The device of claim 14, further comprising a lens structure configured to be removably coupled to the ocular member at the opening. ### Claim 17 (depends on 14) The device of claim 14, wherein the ocular member includes a lip portion at the opening, and wherein the device further comprises a lens structure having an attachment feature shaped to snap into the lip portion of the ocular member. ### Claim 18 (depends on 14) The device of claim 14, wherein the opening is configured to receive one of a plurality of lens structures having varying curvatures. ### Claim 19 (depends on 14) The device of claim 14, further comprising a lens structure having a refractive power to correct for visual acuity. ### Claim 20 (depends on 14) The device of claim 14, wherein, when the ocular member is disposed over the eye, the opening is positioned to receive at least a portion of a contact lens disposed over the anterior surface of the eye. ### Claim 21 (depends on 14) The device of claim 14, wherein the ocular member includes a tapered edge around the opening, and wherein, when the ocular member is disposed over the eye, the tapered edge contacts and forms a seal around a periphery of a contact lens disposed over the anterior surface of the eye.