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AssigneesMiCAN Technologies Inc., Japan as Represented by the Director-General of National Institute Institute of Infectious, Osaka University
InventorsRyosuke Suzuki, Maml Matsuda, Masamichi Muramatsu, Kyoko Saito, Masayoshi Fukasawa, Kentaro Hanada, Atsushi Yamanaka, Kazuo Miyazaki, Misuzu Yamada, Jun Shimizu
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The present invention aims to provide a method for testing the function of antibodies that uses safe antigens and gives results more quickly. The present invention relates to a method for determining antibody-dependent enhancement ability of antibodies, including contacting, in the presence of a test antibody, Fcγ receptor-expressing cell with single round infectious virus particles containing a gene with a region encoding a labeled protein and a region encoding non-structural (NS) proteins 1 to 5 of the yellow fever virus genome, a capsid protein of a virus, and an outer shell protein (Envelope) of a virus, wherein when the measured label is greater than that of a negative control cell, the test antibody is determined to have an antibody-dependent enhancement ability, and the like.
A single round infectious virus particle comprising a gene comprising a region encoding a labeled protein and a region encoding non-structural (NS) proteins 1 to 5 of the yellow fever virus genome, a capsid protein of a virus, and an outer shell protein (Envelope) of an evaluation target virus.
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Dependencies are inferred from the claim text.