Back to results
US 2025/0074997 A1Published application
Development of novel upar single-domain antibody
AssigneePersongen Biotherapeutics (Suzhou) Co., Ltd.
InventorsLin YANG, Fengtao YOU
Life of this patent
Estimating the term…
Abstract
A plurality of anti-UPAR single-domain antibodies are obtained by means of phage display library screening technology. The anti-UPAR single-domain antibody can efficiently bind to UPAR, and has application prospects in the treatment of related diseases.
Claims16
An anti-UPAR single domain antibody, wherein complementarity determining regions (CDRs) of a VHH chain of the anti-UPAR single domain antibody is one or more selected from the group consisting of:
- (1) CDR1 as shown in SEQ ID NO:
- 37, CDR2 as shown in SEQ ID NO:
- 53, and CDR3 as shown in SEQ ID NO:
- 54;
- (2) CDR1 as shown in SEQ ID NO:
- 22, CDR2 as shown in SEQ ID NO:
- 23, and CDR3 as shown in SEQ ID NO:
- 24;
- (3) CDR1 as shown in SEQ ID NO:
- 42, CDR2 as shown in SEQ ID NO:
- 43, and CDR3 as shown in SEQ ID NO:
- 44;
- (4) CDR1 as shown in SEQ ID NO:
- 25, CDR2 as shown in SEQ ID NO:
- 26, and CDR3 as shown in SEQ ID NO:
- 27;
- (5) CDR1 as shown in SEQ ID NO:
- 28, CDR2 as shown in SEQ ID NO:
- 29, and CDR3 as shown in SEQ ID NO:
- 30;
- (6) CDR1 as shown in SEQ ID NO:
- 31, CDR2 as shown in SEQ ID NO:
- 32, and CDR3 as shown in SEQ ID NO:
- 33;
- (7) CDR1 as shown in SEQ ID NO:
- 34, CDR2 as shown in SEQ ID NO:
- 35, and CDR3 as shown in SEQ ID NO:
- 36;
- (8) CDR1 as shown in SEQ ID NO:
- 37, CDR2 as shown in SEQ ID NO:
- 38, and CDR3 as shown in SEQ ID NO:
- 39;
- (9) CDR1 as shown in SEQ ID NO:
- 40, CDR2 as shown in SEQ ID NO:
- 26, and CDR3 as shown in SEQ ID NO:
- 41;
- (10) CDR1 as shown in SEQ ID NO:
- 19, CDR2 as shown in SEQ ID NO:
- 20, and CDR3 as shown in SEQ ID NO:
- 21;
- (11) CDR1 as shown in SEQ ID NO:
- 45, CDR2 as shown in SEQ ID NO:
- 46, and CDR3 as shown in SEQ ID NO:
- 47;
- (12) CDR1 as shown in SEQ ID NO:
- 48, CDR2 as shown in SEQ ID NO:
- 49, and CDR3 as shown in SEQ ID NO:
- 50;
- (13) CDR1 as shown in SEQ ID NO:
- 51, CDR2 as shown in SEQ ID NO:
- 38, and CDR3 as shown in SEQ ID NO:
- 52;
- and
- (14) CDR1 as shown in SEQ ID NO:
- 16, CDR2 as shown in SEQ ID NO:
- 17, and CDR3 as shown in SEQ ID NO:
- 18.
54 more elements
(canceled)
Dependencies are inferred from the claim text.