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US 2025/0074951 A1Published application
Compositions and methods for altering amyloid precursor protein (app) processing
AssigneeDrexel University
InventorsOlimpia Meucci, Renato Brandimarti
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Abstract
The present invention relates to the discovery of compositions and methods for altering Amyloid Precursor Protein (APP) processing. Alerting APP processing is aids the treatment of neuropathological disorders such as those associated with HIV infection and Alzheimer's disease (AD). The invention includes fusion protein constructs that include an effector protein and an HSV US9 protein or functionally active fragment thereof that reduce the amount of amyloid □-protein produced in a cell.
Claims25
A construct comprising:
- an effector protein or a functionally active fragment thereof;
- a Herpes Simplex Virus (HSV) US9 protein or a functionally active fragment thereof, and
- wherein the effector protein or the functionally active fragment thereof is covalently coupled to the HSV US9 protein or the functionally active fragment thereof.
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Dependencies are inferred from the claim text.