Nitrophenyl-acrylamides and uses thereof

A compound, having the following formula:

• or a pharmaceutically acceptable salt thereof,
• wherein
• is a single or double bond;
• R1 is C1-4 alkyl;
• R2 is C1-4 alkylene;
• R3 is N, O, S, NH, CH, or N—(C1-4 alkyl);
• R4 is H, C1-4 alkyl, or (C1-4 alkyl)-OH;
• or R3 and R4 combine to form a C2-6 heterocycloalkyl;
• R5 is C(O)N(H) (C1-4 alkyl), C(O)N(H) (C2-6 heterocycloalkyl), heteroaryl, heteroaryl-(C1-4 alkyl), C(O)H, CN, pyrrolidinonyl, C1-4 alkyl, C1-4 haloalkyl, C(O)O(C1-4 alkyl), C(O)NH2, C(O)N(H) C(O)H, (C1-4 alkyl)-OH, C2-6 heterocycloalkyl-C(O) H, or O—(C1-4 alkyl);
• or R4 and R5 combine to form CO, C3-7 cycloalkyl, C2-6 heterocycloalkyl, pyrrolidinonyl, pyrrolidinonyl-(C1-4 alkyl), or imidazolidinonyl-OH;
• and
• R6 is H, CN, C(O)H, C1-4 alkyl, heteroaryl, O—(C1-4 alkyl), O—(C1-4 alkyl)-OH, N(H)—(C1-4 alkyl), or N(H)—(C1-4 alkyl)-OH.