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US 2025/0074855 A1Published application
Stereoselective preparation of trans halo cyclobutane
AssigneeAmgen Inc.
InventorsAdrian ORTIZ, Athimoolam ARUNACHALAMPILLAI
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Abstract
The present invention relates to stereoselective process for the preparation of a compound having formula (2) and (1) wherein X is defined in the specification.
Claims32
A stereoselective process for the preparation of a compound having formula (2):
- wherein X is halo;
- comprising
- a. contacting a compound of formula (3):
- wherein X is as defined above in compound (2);
- and COOR1 is an ester group;
- with an ester hydrolyzing agent in a solvent;
- to form said compound (2);
- and optionally followed by a process of purifying said compound (2) by
- (a1) contacting said compound (2) with a base in a solvent to form a salt of compound (2);
- and
- (a2) contacting said salt of compound (2) with an acid in a solvent at a low temperature to form a purified form of compound (2).
8 more elements
The process according to claim Error! Reference source not found., further comprising preparing said compound (3) comprising:
- (b) contacting a compound of formula (4):
- wherein said R1 is as defined above in compound (3);
- with a deoxyhalogenating agent in an organic solvent, optionally at a low temperature, to form said compound (3).
Dependencies are inferred from the claim text.