Aromatic vinyl compound, metal complex thereof, and preparation method therefor and use thereof

A compound represented by general formula II or a metal complex thereof, or their tautomers thereof, or their stereoisomers thereof, or their pharmaceutically acceptable salts thereof, or their solvates thereof:

• X1, X2, X3, X4, and X5 are each independently CH or N;
• R1 is hydrogen, halogen, cyano, C1-C4 alkyl, or C1-C4 alkyl substituted by one or more Ra;
• R2 and R3 are each independently hydrogen or halogen;
• R4 is hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkyl substituted by one or more Rb;
• R5 and R6 are each independently hydrogen, deuterium, C1-C4 alkyl, or C1-C4 alkyl substituted by one or more Rc;
• or, R5, R6 together with the nitrogen atom to which they are attached form a 5- to 7-membered heterocyclic ring, or a 5- to 7-membered heterocyclic ring substituted by one or more Rc;
• in the 5- to 7-membered heterocyclic ring, the number of heteroatoms is 1, 2, 3, or 4, and each heteroatom is independently selected from N, O, and S;
• each Ra, each Rb and each Rc are independently deuterium, halogen, hydroxyl, amino, C1-C4 alkyl, C1-C4 alkyl-O—, —COOH, or —C(O)OR9;
• each R8 is independently hydrogen, deuterium, halogen, hydroxyl, amino, C1-C4 alkyl, C1-C4 alkyl-S—, C1-C4 alkyl-O—, —C(O) NH2, —C(O)OC1-4 alkyl, —OR8a, —NHR8a, —NR8aR8b, —NH—C(O)—R8d, C1-C4 alkyl substituted by one or more R8c, C1-C4 alkyl-S— substituted by one or more R8c, or C1-C4 alkyl-O— substituted by one or more R8c;
• or, two adjacent R8 together with the carbon atoms on the benzene ring to which they are attached form a 5- to 7-membered carbocyclic ring, a 5- to 7-membered heterocyclic ring, a 5- to 7-membered carbocyclic ring substituted by one or more C1-4 alkyl, or a 5- to 7-membered heterocyclic ring substituted by one or more C1-4 alkyl;
• in the 5- to 7-membered heterocyclic ring, the number of heteroatoms is 1, 2, 3, or 4, and each heteroatom is independently selected from N and O;
• each R8a, R8b, and each R8c are independently C1-C4 alkyl-S—, halogen, C1-C4 alkyl, C1-C4 alkyl-O—, —COOH, —(C1-C4 alkylene)-COOH, —C(O)OC1-C4 alkyl, —C(O)NH2, —C(O)NHC1-C4 alkyl, 5- to 7-membered heterocyclic ring, or —NR8eR8f;
• in the 5- to 7-membered heterocyclic ring, the species of heteroatoms are independently selected from one or more of N, O, and S, and the number of heteroatoms is independently 1, 2, or 3;
• R8e and R8f are each independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkyl substituted by one or more R8g;
• each R8g is independently halogen, C1-C4 alkyl, hydroxyl, —NR8hR8k, C1-C4 alkyl-O—, —COOH, —(C1-C4 alkylene)-COOH, —C(O)OC1-C4 alkyl, —C(O)NH2, or —C(O)NHC1-C4 alkyl;
• R8h and R8k are each independently hydrogen or C1-C4 alkyl;
• each R8d is independently C6-C10 aryl substituted by one or more R8d-1, or 5- to 10-membered heteroaryl substituted by one or more R8d-2;
• in the 5- to 10-membered heteroaryl, the species of heteroatoms are independently selected from one or more of N, O, and S, and the number of heteroatoms is independently 1, 2, or 3;
• each R8d-1 and R8d-2 are independently C1-C4 alkoxy or C1-C4 alkyl substituted by one or more R8d-1-1;
• each R8d-1-1 is independently 5- to 7-membered heterocyclic ring substituted by one carboxyl;
• in the 5- to 7-membered heterocyclic ring, the species of heteroatoms are independently selected from one or more of N, O, and S, and the number of heteroatoms is independently 1, 2, or 3;
• q is 0, 1, 2, or 3;
• L1 is
• (i) a single bond or —(CH2)n—;
• (ii) —(CH2)m—, in which 1, 2, 3, 4, or 5 non-adjacent CH2 are independently replaced by —Y1—, and each Y1 is independently —C(O)—, —C(O)O—, —O—, —NH—, —C(O)NH—, or —NHC(O)NH—;
• or
• (iii) —(CH2)p—, in which one CH2 is replaced by —Y2—, and the other 0, 1, 2, 3, or 4 non-adjacent CH2 are independently replaced by —Y3—;
• each Y3 is independently —C(O)—, —C(O)O—, —O—, —NH—, —C(O)NH—, or —NHC(O)NH—;
• Y2 is 5- to 7-membered carbocyclic ring or 5- to 7-membered heterocyclic ring;
• in the 5- to 7-membered heterocyclic ring, the number of heteroatoms is 1, 2, 3, or 4, and each heteroatom is independently selected from N, O, and S;
• L1 is unsubstituted or 1, 2, or 3 H contained in L1 are each independently substituted by R7;
• n, m, and p are each independently 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14;
• each R7 is independently C1-C4 alkyl or -L3-R9;
• L3 is
• (i) —(CH2)j—;
• or
• (ii) —(CH2)k—, in which 1, 2, 3, or 4 non-adjacent CH2 are independently replaced by —Y4—, and each Y4 is independently —C(O)—, —C(O)O—, —O—, —NH—, —C(O)NH—, or —NHC(O)NH—;
• L3 is unsubstituted or 1, 2, or 3 H contained in L3 are each independently substituted by R10;
• j and k are each independently 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14;
• R9 is hydrogen, C6-C10 aryl, or C6-C10 aryl substituted by one or more Rd;
• each R10 is independently C1-C4 alkyl;
• each Rd is independently C1-C4 alkyl or C1-C4 alkyl substituted by one or more Re;
• each Re is independently hydroxyl, amino, C1-C4 alkyl, C1-C4 alkyl-O—, —COOH, or —C(O)ORh;
• Rg and Rh are each independently C1-C4 alkyl or halogenated C1-C4 alkyl;
• L2 is metal chelating group;
• the metal complex is a complex chelated by the compound represented by general formula II with a metal atom or ion.