Loading patent…
AssigneeBoston Scientific Scimed, Inc.
InventorsJoseph T. Delaney, JR., Kolbein K. Kolste, Tatyana Dyndikova
Estimating the term…
In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymer arms, wherein a first portion of the polymer arms comprise a reactive end group and wherein a second portion of the polymer arms comprise a branched end group that comprise a plurality of covalently attached diagnostic and/or therapeutic groups, which may be, for example, radiocontrast groups or radioactive groups. Other aspects pertain to a system that comprises (a) a first composition comprising such a polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group of the multi-arm polymer. Still other aspects pertain to a crosslinked reaction product of (a) such a polymer and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end group of the multi-arm polymer.
A composition comprising a multi-arm polymer comprising three or more polymer arms, wherein a first portion of the polymer arms comprise a reactive end group and wherein a second portion of the polymer arms comprise a branched end group that comprise a plurality of covalently attached radiocontrast groups or radioactive groups, wherein the branched end group comprises an acyclic or cyclic hydroxy-polycarboxylic residue core, an acyclic or cyclic polyamine residue core, an oligolysine residue core, or a polyamidoamine core.
A system comprising (a) a first composition comprising a multi-arm polymer comprising three or more polymer arms, wherein a first portion of the polymer arms comprise a reactive end group and wherein a second portion of the polymer arms comprise a branched end group that comprise a plurality of covalently attached radiocontrast groups or radioactive groups, wherein the branched end group comprises an acyclic or cyclic hydroxy-polycarboxylic residue core, an acyclic or cyclic polyamine residue core, an oligolysine residue core, or a polyamidoamine core and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups selected from the group consisting of amine groups and thiol groups that are reactive with the reactive end group such that a crosslinked reaction is formed.
A composition comprising a multi-arm polymer comprising three or more polymer arms, wherein a first portion of the polymer arms comprises an electrophilic end group, and wherein a remaining portion of the polymer arms comprises a branched end group that comprises between 3 and 7 branches, each comprising a covalently attached monocyclic or multicyclic aromatic structure that comprises (i) a plurality of C1-C4-hydroxyalkyl groups and (ii) a plurality of radiopaque functional groups or a plurality of radionuclide groups, wherein the first portion of the polymer arms corresponds to between 60% and 95% of a total number of the polymer arms in the first composition and wherein the second portion of the polymer arms corresponds to between 40% and 5% of the total number of the polymer arms in the first composition.
Dependencies are inferred from the claim text.