Nitrite formulations and their use as nitric oxide prodrugs
AssigneesBoard of Regents, The University of Texas System, Human Power of N Company
InventorsNathan S. Bryan, Janet Zand
Life of this patent
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Abstract
Compositions comprising from about 40 weight parts to about 1000 weight parts of a botanical nitrate source; from about 20 weight parts to about 500 weight parts of a botanical source of nitrite reduction activity; and from about 4 weight parts to about 100 weight parts of a nitrite salt. Use of said composition in methods of reducing triglycerides or reducing C-reactive protein levels are also provided.
Claims23
A composition, comprising:
- from about 40 weight parts to about 1000 weight parts of a botanical nitrate source;
- from about 20 weight parts to about 500 weight parts of a botanical source of nitrite reduction activity;
- and from about 4 weight parts to about 100 weight parts of a nitrite salt.
A method of reducing a patient's triglyceride level, comprising:
- administering to the patient a composition in a form of a lozenge dissolvable in the mouth, the composition comprising:
- from about 40 weight parts to about 1000 weight parts of a botanical nitrate source;
- from about 20 weight parts to about 500 weight parts of a botanical source of nitrite reduction activity;
- from about 20 weight parts to about 500 weight parts L-citrulline;
- and from about 4 weight parts to about 100 weight parts of a nitrite salt.
A method of reducing a patient's C-reactive protein level, comprising:
- administering to the patient a composition in a form of a lozenge dissolvable in the mouth, the composition comprising:
- from about 40 weight parts to about 1000 weight parts of a botanical nitrate source;
- from about 20 weight parts to about 500 weight parts of a botanical source of nitrite reduction activity;
- from about 20 weight parts to about 500 weight parts L-citrulline;
- and from about 4 weight parts to about 100 weight parts of a nitrite salt.
Dependencies are inferred from the claim text.