Modulated weight reduced ferrule canister

A system for validating a sealing of a pharmaceutical container, the system comprising:

• a vacuum chamber configured to apply a negative pressure to at least one pharmaceutical container within the vacuum chamber;
• a mass spectrometer in fluid communication with the vacuum chamber;
• and,
• a controller configured to perform validation operations, the validation operations comprising:
• apply a negative pressure to the at least one pharmaceutical container;
• retrieve a spectrometer calibration profile, wherein the spectrometer calibration profile comprises a predetermined correlation between a molecule count of the spectrometer and a weight change in the pharmaceutical container over a predetermined period;
• and,
• determine, as a function of the spectrometer calibration profile and a detected molecule count by the mass spectrometer of a leaked substance from the pharmaceutical container, an equivalent weight change in the pharmaceutical container over the predetermined period.

A method for validating a sealing of a pharmaceutical container, the method comprising:

• providing a vacuum chamber configured to apply a negative pressure to at least one pharmaceutical container within the vacuum chamber;
• providing a mass spectrometer in fluid communication with the vacuum chamber;
• and,
• providing a controller configured to perform validation operations, the validation operations comprising:
• applying a negative pressure to the at least one pharmaceutical container;
• retrieving a spectrometer calibration profile, wherein the spectrometer calibration profile comprises a predetermined correlation between a molecule count of the spectrometer and a weight change in the pharmaceutical container over a predetermined period;
• and,
• determining, as a function of the spectrometer calibration profile and a detected molecule count by the mass spectrometer of a leaked substance from the pharmaceutical container, an equivalent weight change in the pharmaceutical container over the predetermined period.