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US 2025/0066411 A1Published application
Glycomimetic binders for l-sign
AssigneesUniversita' Degli Studi Di Milano, Universite Grenoble Alpes, Commissariat A L' Energie Atomique Et Aux Energies Alternatives, Centre National De La Recherche Scientifique
InventorsAnna BERNARDI, Sara POLLASTRI, Clara DELAUNAY, Michel THÉPAUT, Franck FIESCHI, Gianluca CAVAZZOLI
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Abstract
The present invention relates to new glycomimetic molecules which selectively bind to the L-SIGN receptor, finding application in the medical field and, in particular, in the prevention and treatment of viral infections, in the immunotherapy of liver tumors and in the treatment of immune diseases.
Claims20
A compound of formula (I) or a salt thereof,
- where R is selected from the group consisting of:
- C1-C6 alkyls, C3-C6 cycloalkyls, C6-C10 aryls, —R2Cl,
- —R3NH2, —R4NHC(O) R′, —R5SR″, —R6OR″, and
- where:
- p is an integer between 0 and 3;
- q is an integer between 1 and 3;
- R2, R3, R4, R5 are divalent radicals selected from the group consisting of C1-C6 alkylenes and C3-C6 cycloalkylenes;
- and
- R′, R″ are selected from the group consisting of C1-C6 alkyls, C3-C6 cycloalkyls, C6-C10 aryls, R″′ is selected from the group consisting of —OH and halogens,
- and where R1 has formula (II):
- where:
- X is selected from the group consisting of CH2, O, NH and S;
- Y is selected from the group consisting of O, NH and S;
- n is an integer between 0 and 3;
- m is an integer between 0 and 3;
- W is a heterocyclic substituent W1 selected from the group consisting of:
- or it is a substituent W2 having general formula
- where:
- X1 is selected from the group consisting of H and C1-C6 alkyls;
- X2 is selected from the group consisting of H, OCH3, OH, NH2, CH3, CF3, SH, SR, halogen, where R is as defined above;
- n1 is an integer selected between 1 and 2;
- Z is selected from the group consisting of S and NRa, in which Ra and Rb are independently selected from the group consisting of H, COR7, COOR8, CONHR9, where R7, R8 and R9 are H, C1-C6 alkyls, C3-C6 cycloalkyls, or C6-C10 aryls;
- or compound of formula (IA) or a salt thereof,
- A-(B)-C-(B)-A (IA)
- in which:
- where R′, p and q are as defined above.
23 more elements
Dependencies are inferred from the claim text.