Biguanide derivative of ibuprofen and process of preparation thereof

A process for synthesis of biguanide derivative of ibuprofen, the process comprising:

• reacting ibuprofen with chloroform under anhydrous condition to form a first reaction mixture;
• adding dimethylformamide (DMF) to the first reaction mixture to form a second reaction mixture;
• adding thionyl chloride (SOCl2) to the second reaction mixture under nitrogen environment;
• removing excess dichloromethane and SOCl2 from the second reaction mixture by distillation;
• adding petroleum ether to the second reaction mixture to obtain acid chloride of ibuprofen;
• extracting, washing and drying the acid chloride of ibuprofen to obtain of 2-(4-isobutylphenyl) propanehydrazide;
• adding 4-isobutylphenyl) propanehydrazide an alcoholic solution followed by addition of dicyandiamide to form a third reaction mixture;
• extracting, washing, and drying the third reaction mixture to obtain Ibuprofen biguanide monohydrochloride.