Dihydrazide-dihydrazone compounds with adamantyl moiety and a process for synthesis of the same
OwnerRupa Sachin Pawarinventor
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Abstract
The present disclosure relates generally to organic compounds. More specifically, the disclosure is directed to a dihydrazide-dihydrazone compound of Formula (I), a stereoisomer, a tautomer, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof. The compounds of the present disclosure possess anti-microbial activity, specifically antifungal and antibacterial activity. The present disclosure also provides a process of synthesis of the compound of Formula (I).
Claims13
A compound of Formula I, a stereoisomer, a tautomer, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof,
- wherein R1 is an unsubstituted or substituted C6-10 aryl or an unsubstituted or substituted C4-10 heterocyclyl;
- R2 is selected from H, C1-6alkyl, C1-6alkoxy, halogen, nitro, —COOH or combinations thereof;
- and
- wherein the substituents are selected from one or more of halogen, nitro, C1-6alkyl, C1-6alkoxy, —COOH, hydroxy, cyano, or NH2.
A process of synthesis of a compound of Formula I, a stereoisomer, a tautomer, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof comprising the steps of:
- (a) reacting a dimethyl-1,3-adamantane-di-carboxylate compound of Formula IV with hydrazine hydrate in the presence of an alcoholic solution to give a dihydrazide compound of Formula III;
- and
- (b) refluxing the compound of Formula III with a compound of Formula II in the presence of a solvent to give the compound of Formula I
Dependencies are inferred from the claim text.