US 2025/0065076 A1Published application

Urinary system catheter using ethanol extract of propolis as coating and preparation method thereof

AssigneeSichuan University

InventorLuo Yang

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Abstract

A urinary system catheter is covered by an ethanol extract of propolis on a surface of the urinary system catheter. The EEP is used as a coating material of the urinary system catheter to prepare an antimicrobial urinary system catheter. The EEP serving as a surface coating can enhance surface hydrophilicity of the urinary system catheter, and clinical operation of the urinary system catheter is facilitated. Meanwhile, the EEP serving as the surface coating can prevent a bacterial biofilm from being formed on the surface of the urinary system catheter, thereby possessing antimicrobial and anti-infective effects, and a high anti-scab capacity. In addition, propolis is a natural substance, has the advantages of good biocompatibility and low cost, and is suitable for mass production. The urinary system catheter prepared by using the EEP as the coating has a good application prospect.

Claims17

Dependent claims

An antimicrobial and anti-infective urinary system catheter, comprising:

a surface of an urinary system catheter;
and
a coating of a propolis alcohol extract directly covered on the surface of the urinary system catheter, to enhance hydrophilicity of the surface of the urinary system catheter, prevent stones and scabs forming on the surface of the urinary system catheter, and make the urinary system catheter antimicrobial and anti-infective;
wherein the coating of the propolis alcohol extract comprises:
total flavonoids and total phenolic acid, and an average surface propolis content of the coating of the propolis alcohol extract is greater than or equal to 0.721 according to the following formula for calculating the average surface propolis content:
total
⁢
flavonoids
⁢
content
⁢
in
⁢
solution
/
274.4
+
total
⁢
phenolic
⁢
acid
⁢
content
⁢
in
⁢
solution
/
143.7
2
×
surface
⁢
area
⁢
of
⁢
segment
where total flavonoids content in solution represents content of the total flavonoids in a dissolved solution of the coating of the propolis alcohol extract, total phenolic acid content in solution represents content of the total phenolic acid in the dissolved solution of the coating of the propolis alcohol extract, surface area of segment represents an area of the surface of the urinary system catheter coated with the coating of the propolis alcohol extract;
and
wherein an contact angle between the coating of the propolis alcohol extract covered on the surface of the urinary system catheter and water is less than 90°.

39 more elements

Dependencies are inferred from the claim text.

Facts

Application: 18/733,907Filed 5 Jun 2024
Priority: CN 202311081697525 Aug 2023
Published: 27 Feb 2025
Term ends: Not estimatedThe source records don’t support an estimate.

Classification24 codes

A61M 25/0017
Catheters; Hollow probes: specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
A61K 35/644
Insects, e.g. bees, wasps or fleas: beeswax; Propolis; Royal jelly; Honey
A61L 27/54
Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface…:…
A61L 29/08
Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters: materials for coatings