Compositions and methods for treating a cardiac disease
AssigneeChildren's Medical Center Corporation
InventorsVassilios J. Bezzerides, William J. Pu, Sofia M. De La Serna Buzon
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Abstract
The invention of the disclosure features Ca2+-calmodulin dependent kinase II (CaMKII) inhibitory multimeric polypeptides polynucleotides encoding such polypeptide, and methods of using the same for the treatment of cardiac diseases (e.g., catecholaminergic polymorphic ventricular tachycardia (CPVT) or atrial fibrillation (AF)).
Claims20
A multimeric polypeptide that inhibits CaMKII.
A method of treating a subject having a cardiac disease, condition, or disorder characterized by a cardiac arrhythmia, comprising administering a multimeric AIP polypeptide or a polynucleotide encoding said polypeptide to the subject.
A method of treating a subject having a cardiac disease, condition, or disorder characterized by a cardiac arrhythmia, comprising administering an effective amount of an adeno-associated viral vector comprising a polynucleotide encoding a multimeric AIP polypeptide to the subject.
A method of reducing cardiac variability in a subject having atrial fibrillation, comprising administering a multimeric AIP polypeptide or a polynucleotide encoding said multimeric AIP polypeptide to the subject.
Dependencies are inferred from the claim text.