Engineered pnma proteins and delivery systems thereof
AssigneesThe Broad Institute, Inc., Massachusetts Institute of Technology
InventorsFeng Zhang, Victoria Madigan, Yugang Zhang, Rumya Raghavan, Max Wilkinson, Guilhem Faure, Rhiannon Macrae
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Abstract
Described herein are engineered paraneoplastic Ma protein (PNMA) capable of forming a capsid. In some embodiments, the engineered PNMA proteins comprise one or more modifications that enhance binding or loading of a cargo into the capsid, one or more modifications that modify cell-specificity of the capsid, one or more modifications that enhance intracellular delivery of the capsid, or a combination thereof. Also described herein are delivery systems comprising capsids comprising an engineered PNMA protein and a cargo.
Claims38
An engineered paraneoplastic Ma protein (PNMA) capable of forming a capsid and comprising one or more modifications that enhance binding or loading of a cargo into the capsid, one or more modifications that modify cell-specificity of the capsid, one or more modifications that enhance intracellular delivery of the capsid, or any combination thereof.
Dependencies are inferred from the claim text.