Compositions and methods for treating celiac sprue disease
OwnerIngrid Swanson PULTZ, Clancey WOLF +4inventors
InventorsIngrid Swanson PULTZ, Clancey WOLF, Justin Bloomfield SIEGEL, Christine Elaine TINBERG, Lance STEWART, David BAKER
Life of this patent
Estimating the term…
Abstract
The present disclosure is directed to polypeptides capable of cleaving gluten proteins, e.g., gliadins, nucleic acid molecules encoding the same, pharmaceutical compositions comprising the same, and methods of use thereof for treating celiac sprue disease and/or non-celiac gluten sensitivity (NCGS).
Claims27
A polypeptide comprising an amino acid sequence having at least about 75% sequence identity to the amino acid sequence set forth in SEQ ID NO:
- 1, wherein the first amino acid at the N-terminus of the polypeptide is a Ser (S).
(canceled)
A polypeptide comprising an amino acid sequence having at least about 75% sequence identity to the amino acid sequence set forth in SEQ ID NO:
- 23, wherein the Xaa in SEQ ID NO:
- 23 is not a Met (M).
A polypeptide comprising an amino acid sequence having at least about 75% sequence identity to the amino acid sequence set forth in SEQ ID NO:
- 1, wherein the first amino acid at the N-terminus of the polypeptide is a Ser (S);
- wherein the polypeptide comprises the amino acid sequence set forth in SEQ ID NO:
- 8.
-7. (canceled)
(canceled)
(canceled)
-23. (canceled)
(canceled)
-30. (canceled)
Dependencies are inferred from the claim text.