Cancer therapy with live attenuated bacteria
AssigneeProkarium Limited
InventorsLivija Deban, Nicholas Glanville
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Abstract
The present invention relates to the field of cancer therapy. In particular, the present invention relates to a first composition comprising a live attenuated bacterium for use in the treatment, prevention, reduction, inhibition, prevention of recurrence, or control of a neoplastic disease in a subject being or intended to be administered a second composition comprising a live attenuated bacterium, said bacterium being the same or different to that of the first composition and methods thereof.
Claims20
A method of treating, reducing, inhibiting, or controlling a neoplastic disease in a subject, wherein the method comprises administering to the subject
- (i) a first composition comprising a live attenuated Gram-negative bacterium, and
- (ii) a second composition comprising a live attenuated Gram-negative bacterium, said live attenuated Gram-negative bacterium being the same or different to that of the first composition,
- wherein the first composition is administered orally, intravenously, intranasally, intradermally or via subcutaneous delivery to stimulate a systemic immune response in the subject, and
- wherein the first composition is administered simultaneously, separately or sequentially with the second composition, and
- wherein the second composition is for administration locally to the site of the neoplastic disease.
Dependencies are inferred from the claim text.