Vaccination with mica/b alpha 3 domain for the treatment of cancer
AssigneeDana-Farber Cancer Institute, Inc.
InventorsKai W. Wucherpfennig, Soumya Badrinath
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Abstract
The present invention provides compositions and methods for treating cancer in a subject by eliciting an immune response against a MIC alpha 3-domain polypeptide.
Claims34
-22. (canceled)
A vaccine composition comprising, as an immunogenic component, an effective amount of a peptide comprising of a MIC alpha 3-domain peptide, the effective amount being an amount effective to elicit an immune response against the MIC alpha 3-domain peptide, wherein the peptide comprises the amino acid sequence of SEQ ID NO:
- 3 or SEQ ID NO:
- 4.
A vaccine composition comprising, as an immunogenic component, a peptide comprising the amino acid sequence of SEQ ID NO:
- 3 or SEQ ID NO:
- 4, wherein the vaccine composition further comprises mesoporous silica, a GM-CSF polypeptide or fragment thereof, and a CpG oligonucleotide or fragment thereof.
A synthetic nucleic acid encoding a MIC alpha 3-domain peptide, wherein the peptide comprises the amino acid sequence of SEQ ID NO:
- 3 or SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.