Tranexamic acid spray for knee arthroplasty
AssigneeShilpa Medicare Limited
InventorsVara Prasad RANGABHATLA GUNNESWARA SUBRAMANYA, Sai Laxmi Aparna RANGABHATLA, Ratna Phani AYALASOMAYAJULA
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Abstract
The present invention relates to novel formulations comprising a sprayable composition comprising tranexamic acid and chitosan for use in the treatment of wounds or injuries, in particular for use as a topical hemostatic composition or for surgical intervention and the process for preparation thereof.
Claims21
1-10. (canceled)
A topical spray composition comprising about 1% w/w to about 10% w/w tranexamic acid, about 0.1% w/w to about 1% w/w chitosan, and water, wherein the tranexamic acid and the chitosan are present in ratio of at least about 2.5:1, respectively.
A topical spray composition comprising tranexamic acid, chitosan, water, and glacial acetic acid, wherein the tranexamic acid and the chitosan are present in ratio of at least about 2.5:1, respectively.
A method of treating a wound or reducing bleeding at a hemorrhaging site, comprising administering the topical spray composition of claim 1.
A method of preparing the topical spray composition of claim 1, comprising
- a) dissolving Chitosan in 1% glacial acetic acid;
- b) dissolving tranexamic acid in the solution of a);
- c) adding water;
- and
- d) sterilizing by filtration.
A topical spray composition comprising about 10% w/w tranexamic acid, about 0.2% w/w chitosan, water, and glacial acetic acid.
Dependencies are inferred from the claim text.