Method of treating an autoimmune disease by administering an anti-human baff antibody
AssigneesTsutomu Takeuchi, Keiko Yoshimoto, Kowa Company, Ltd.
InventorsTsutomu Takeuchi, Keiko Yoshimoto
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Abstract
An antibody against a peptide having an amino acid sequence AVQGPEETVT QDC (expressed in single letter amino acid code) as represented by SEQ ID: NO1 corresponding to the 134- to 146-positions in human BAFF (B cell activating factor belonging to the TNF family) protein which is preferably a monoclonal antibody; a method of producing the above antibody; a medicinal composition containing the antibody; utilization of the antibody; and a method of screening an inhibitory effect or an activating effect on BAFF with the use of the antibody.
Claims9
A method of detecting or quantifying BAFF (B cell activating factor belonging to the TNF family) in a sample, which comprises adding an isolated antibody to a sample and measuring BAFF bound to the antibody,
- wherein the isolated antibody is directed against a peptide consisting of an amino acid sequence of SEQ ID No:1 which is the amino acid sequence of the 134- to 146-positions in human BAFF protein.
A method of preventing or treating an autoimmune disease, comprising:
- administering an effective amount of an isolated antibody to a patient who needs to inhibit a function of human B cell activating factor belonging to a TNF family to prevent or treat the autoimmune disease,
- wherein the isolated antibody is directed against a peptide consisting of an amino acid sequence of SEQ ID No:1 which is the amino acid sequence of the 134- to 146-positions in human BAFF protein.
A method for diagnosing an autoimmune disease, comprising:
- measuring a concentration of BAFF in serum or tissue collected from a subject using an isolated antibody directed against a peptide consisting of an amino acid sequence of SEQ ID No:1 which is the amino acid sequence of the 134- to 146-positions in human BAFF protein, wherein the autoimmune disease is selected from SLE, RA and SS.
Dependencies are inferred from the claim text.