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AssigneeFlagship Pioneering Innovations VI, LLC
InventorsBradley Joseph Kubick, Douglas Ewen Cameron, Christa Elyse Osuna, Nicolas Cordero, Edwin Xavier Arauz Diaz, Syandan Chakraborty, Lee John Flaherty, Alok Das Mohapatra, Pratibha Singh
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Compositions comprising donor cells, acceptor cells, and methods involving the same are described herein. In some embodiments, the donor cell is deficient in at least one endogenous function, for instance cytotoxic activity. In some embodiments, the donor cell comprises a T cell receptor (TCR) and a cargo, and the acceptor cell comprises an MHC. In some embodiments, the TCR facilitates transfer of the cargo to the acceptor cell. In some embodiments, the donor cell comprises a chimeric antigen receptor (CAR) and a cargo, and the acceptor cell comprises an antigen bound by the CAR. In some embodiments, the CAR facilitates transfer of the cargo to the acceptor cell.
A donor cell comprising:
13-16. (canceled)
A donor cell comprising:
A donor cell comprising:
Dependencies are inferred from the claim text.