Viral vector constructs for delivery of nucleic acids encoding cytokines and uses thereof for treating cancer
AssigneeKriya Therapeutics, Inc.
InventorsBrian FURMANSKI, Nachiketa GUPTA, Bruce SCHNEPP, Michele STONE
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Abstract
The present disclosure provides the gene therapy compositions comprising vectors (e.g., viral vectors) suitable for delivery of nucleic acids encoding immunomodulatory proteins or functional fragments thereof, and methods of using the same. Certain aspects of the disclosure are directed to an adeno-viral vector (AAV) delivery of nucleic acids encoding two or more immunomodulatory proteins or functional fragments thereof to a tumor.
Claims24
1-14. (canceled)
A method of treating a subject suffering from a tumor comprising administering a combination therapy to the subject, wherein the combination therapy comprises:
- (a) a first composition comprising an adeno-associated virus (AAV) vector comprising a polynucleotide comprising (i) a promoter, (ii) a first nucleic acid encoding a first Interleukin-12 (IL-12) subunit or functional fragment thereof, (iii) a translation modification sequence, and (iv) a second nucleic acid encoding a second IL-12 subunit or functional fragment thereof;
- and (b) a second composition comprising a checkpoint inhibitor.
21-78. (canceled)
80-116. (canceled)
118-132. (canceled)
Dependencies are inferred from the claim text.