Cell death-inducing dffa-like effector b (cideb) irna compositions and methods of use thereof

A double stranded ribonucleic acid (dsRNA) agent for inhibiting expression of cell death-inducing DFFA-like effector b (CIDEB) in a cell, wherein said dsRNA agent comprises a sense strand and an antisense strand forming a double stranded region, wherein the sense strand consists of the nucleotide sequence,

• (SEQ ID NO:
• 705)
• 5′-AGUAUCUAAUAUAAGCUCGGU-3′,
• and the antisense strand consists of the nucleotide sequence,
• SEQ ID NO:
• 1153
• 5′-ACCGAGCUUAUAUUAGAUACUGA-3′
• wherein substantially all of the nucleotides of the sense strand and substantially all of the nucleotides of the antisense strand are modified nucleotides;
• wherein the dsRNA agent is conjugated to a ligand at the 3′ end of the sense strand;
• and
• wherein the ligand is

A double stranded ribonucleic acid (dsRNA) agent comprising a sense strand and an antisense strand forming a double stranded region, wherein the antisense strand comprises the nucleotide sequence,

• 5′-asdCscgdAgdCuuaudAuUfagauacusgsa-3′ (SEQ ID. NO:
• 2049),
• wherein
• s is a phosphorothioate linkage;
• a, c, g, and u are 2′-O-methyl (2′-OMe) A, C, G, and U, respectively;
• dA and cA are 2′-deoxy A and 2′-deoxy C, respectively;
• and
• Uf is 2′-deoxy-2′-fluoro (2′-F) U.

A double stranded ribonucleic acid (dsRNA) agent, or a pharmaceutically acceptable salt thereof, comprising a sense strand and an antisense strand forming a double stranded region, wherein the sense strand consists of the nucleotide sequence,

• 5′-asgsuaucuaAfUfAfuaagcucgguL96-3′ (SEQ ID. NO:
• 1601),
• and the antisense strand consists of the nucleotide sequence,
• 5′-asdCscgdAgdCuuaudAuUfagauacusgsa-3′ (SEQ ID. NO:
• 2049),
• wherein
• s is a phosphorothioate linkage;
• a, c, g, and u are 2′-O-methyl (2′-OMe) A, C, G, and U, respectively;
• dA and cA are 2′-deoxy A and 2′-deoxy C, respectively;
• and
• Af and Uf are 2′-deoxy-2′-fluoro (2′-F) A and U, respectively.