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US 2025/0059527 A1Published application
Targeted degradation of alpha-synuclein
AssigneeUniversity of Dundee
InventorGopal SAPKOTA
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Abstract
The present invention relates to a proteasomal degradation protein complex that comprises an E3 ubiquitin ligase component tethered to an α-synuclein-specific polypeptide binder for degradation of α-synuclein. The present invention also comprises a mechanism of action, composition and related methods for the treatment of neurological disorders including synucleopathies.
Claims32
A proteasomal degradation protein complex comprising an E3 ubiquitin ligase component tethered to an α-synuclein-specific polypeptide binder;
- wherein the proteasomal degradation protein complex is capable of targeting α-synuclein for proteasomal degradation.
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Dependencies are inferred from the claim text.