Method for operating a clarification setup

A method for operating a clarification setup of a bioprocess installation, wherein the clarification setup comprises a fluidized bed centrifuge for the clarification of a cell broth by centrifugation and a pumping arrangement assigned to the fluidized bed centrifuge, wherein the fluidized bed centrifuge comprises at least one centrifuge chamber, which is being turned around a geometrical centrifuge axis, wherein the bioprocess installation comprises an electronic process control for controlling at least the fluidized bed centrifuge and the pumping arrangement, wherein the fluidized bed centrifuge is being operated in a forward operation for a particle loading cycle and/or a particle washing cycle and in a backward operation for a particle discharging cycle, wherein in the case where a particle loading cycle is provided, during the particle loading cycle, cell broth loaded into the centrifuge chamber proceeds to form a growing particle accumulation in the centrifuge chamber, wherein the clarification setup comprises a monitoring sensor arrangement with at least one optical sensor for producing monitoring sensor data, which are being transmitted to the electronic process control,

• wherein in a monitoring routine, image-related data representing an optical image of the centrifuge chamber content are being produced by the monitoring sensor arrangement and a particle filling level is being calculated by the electronic process control from the image-related data based on a calculation model.