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AssigneeCelldex Therapeutics, Inc.
InventorsTibor KELER, Joel GOLDSTEIN, Lizhen HE, Henry C. MARSH, Karuna SUNDARAPANDIYAN, Lawrence J. THOMAS, Laura A. VITALE, Jenifer WIDGER
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The invention provides CD27 agonists comprising a first component that is an anti-CD27 antibody, or antigen-binding fragment thereof, linked to a second component comprising one or more cross-linking moieties. At least one of the cross-linking moieties does not bind to an Fc receptor and the CD27 agonist stimulates T cell activity without the need for Fc receptor interaction. The cross-linking molecule(s) can be, for example, an anti-CD27, antibody, or antigen-binding fragment thereof, that can be the same or different than the first component. Alternatively, the cross-linking molecule(s) can be a CD27 ligand or a molecule (e.g., antibody) that binds a molecule on a cell such as a T cell, a tumor cell or a stromal cell. Pharmaceutical compositions comprising the CD27 agonists, and methods of using the CD27 agonists, are also provided.
1-74. (canceled)
A CD27 agonist comprising a first component that is an anti-CD27 antibody, or antigen-binding fragment thereof, linked to a second component comprising one or more cross-linking moieties, wherein:
A CD27 agonist comprising a first component that is an anti-CD27 antibody, or antigen-binding fragment thereof, linked to a second component comprising one or more cross-linking moieties having a binding specificity that is the same as the first component, wherein the CD27 agonist stimulates T cell activity without the need for Fc receptor interaction.
A CD27 agonist comprising a first component that is an anti-CD27 antibody, or antigen-binding fragment thereof, linked to a second component comprising a CD27 ligand, wherein the CD27 agonist stimulates T cell activity without the need for Fc receptor interaction.
Dependencies are inferred from the claim text.