Galectin-10 antibodies
Assigneeargenx BV
InventorsPaul Sebastian VAN DER WONING, Jean-Michel PERCIER
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Abstract
The present invention relates to antibodies and antigen binding fragments thereof that bind to the protein galectin-10, particularly human galectin-10. The galectin-10 antibodies and antigen binding fragments of the invention, disrupt the crystallization of galectin-10 and are therefore useful in methods of preventing and treating diseases and conditions wherein the pathology is linked to the formation/presence of Charcot-Leyden crystals (CLCs).
Claims17
An antibody or antigen binding fragment thereof that binds to galectin-10, wherein the antibody or antigen binding fragment comprises a heavy chain variable domain (VH) and a light chain variable domain (VL) wherein:
- (i) the VH comprises ta HCDR3 comprising the amino acid sequence of SEQ ID NO:
- 2;
- a HCDR2 comprising the amino acid sequence of SEQ ID NO:
- 3;
- and a HCDR1 comprising the amino acid sequence of SEQ ID NO:
- 1;
- and
- (ii) the VL comprises a LCDR3 comprising the amino acid sequence of SEQ ID NO:
- 8;
- a LCDR2 comprising the amino acid sequence of SEQ ID NO:
- 9;
- and a LCDR1 comprising the amino acid sequence of SEQ ID NO:
- 7.
11-15. (canceled)
21-23. (canceled)
Dependencies are inferred from the claim text.