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US 2025/0059281 A1Published application
High affinity b7-h6 antibodies and antibody fragments
AssigneeTrustees of Dartmouth College
InventorsMargaret Ackerman, Casey Hua, Charles Sentman
Life of this patent
Estimating the term…
Abstract
Provided herein, in some embodiments, are antibodies, antigen-binding antibody fragments, chimeric antigen receptors (CARs) and bispecific T cell engagers (BiTEs) that bind specifically to B7 homolog 6. Also provided herein are methods of using the same and cells comprising the same.
Claims20
1-69. (canceled)
An antibody or antigen-binding antibody fragment that binds specifically to B7 homolog 6 (B7-H6) which comprises any of the following:
- I. (a) a heavy chain variable region comprising,
- (i) a CDR1 of SEQ ID NO:
- 4,
- (ii) a CDR2 of SEQ ID NO:
- 5, and
- (iii) a CDR3 of SEQ ID NO:
- 6;
- and
- (b) a light chain variable region comprising,
- (i) a CDR1 of SEQ ID NO:
- 7,
- (ii) a CDR2 of SEQ ID NO:
- 8, and
- (iii) a CDR3 of SEQ ID NO:
- 9;
- or
- II. (a) a heavy chain variable region comprising,
- (i) a CDR1 of SEQ ID NO:
- 13,
- (ii) a CDR2 of SEQ ID NO:
- 14, and
- (iii) a CDR3 of SEQ ID NO:
- 15;
- and
- (b) a light chain variable region comprising,
- (i) a CDR1 of SEQ ID NO:
- 16,
- (ii) a CDR2 of SEQ ID NO:
- 17, and
- (iii) a CDR3 of SEQ ID NO:
- 18
- or
- (III). (a) a heavy chain variable region comprising,
- (i) a CDR1 of SEQ ID NO:
- 22,
- (ii) a CDR2 of SEQ ID NO:
- 23, and
- (iii) a CDR3 of SEQ ID NO:
- 24;
- and
- (b) a light chain variable region comprising,
- (i) a CDR1 of SEQ ID NO:
- 25,
- (ii) a CDR2 of SEQ ID NO:
- 26, and
- (iii) a CDR3 of SEQ ID NO:
- 27;
- or
- IV. (a) a heavy chain variable region comprising,
- (i) a CDR1 of SEQ ID NO:
- 31
- (ii) a CDR2 of SEQ ID NO:
- 32, and
- (iii) a CDR3 of SEQ ID NO:
- 33;
- and
- (b) a light chain variable region comprising,
- (i) a CDR1 of SEQ ID NO:
- 34,
- (ii) a CDR2 of SEQ ID NO:
- 35, and
- (iii) a CDR3 of SEQ ID NO:
- 36;
- or
- V. (a) a heavy chain variable region comprising an amino acid sequence that is
- (i) identical to SEQ ID NO:
- 2, 11, 20 or 29, or
- (ii) at least 90% identical to SEQ ID NO:
- 2, 11, 20 or 29 and
- comprises at least one mutation in at least one framework region in SEQ ID NO:
- 2, 11, 20 or 29, respectively;
- and
- (b) a light chain variable region comprising an amino acid sequence that is
- (i) identical to SEQ ID NO:
- 3, 12, 21 or 30, or
- (ii) at least 90% identical to SEQ ID NO:
- 33, 12, 21 or 30 and
- comprises of at least one mutation in at least one framework region in SEQ ID NO:
- 3, 12, 21 or 30, respectively.
76 more elements
Dependencies are inferred from the claim text.