Method of treating stroke
AssigneeAlaMab Therapeutics, Inc.
InventorYanfeng Zhang
Life of this patent
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Abstract
The present disclosure provides compositions and methods of treating a stroke in a subject. The method comprises blocking the opening of connexin 43 (Cx43) hemichannel in cells by, e.g., using a composition comprising an anti-Cx43 antibody.
Claims43
A method for treating a stroke in a subject, comprising administering to the subject at least one dose of an anti-connexin 43 (Cx43) antibody, wherein the anti-Cx43 antibody comprises heavy chain CDR sequences and light chain CDR sequences as follows:
- HCDR1:
- SEQ ID NO:
- 1;
- HCDR2:
- SEQ ID NO:
- 2;
- HCDR3:
- SEQ ID NO:
- 3;
- LCDR1:
- SEQ ID NO:
- 4;
- LCDR2:
- SEQ ID NO:
- 5;
- and
- LCDR3:
- SEQ ID NO:
- 6.
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A method for treating a stroke in a subject, comprising administering to the subject an effective amount of an anti-connexin 43 (Cx43) antibody, wherein the anti-Cx43 antibody is administered according to the following dosing regimen:
- i) a first dose within one week from the stroke, and
- ii) a second dose within a month from the stroke.
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Dependencies are inferred from the claim text.