Multi-specific antigen binding molecules targeting hiv and methods of use

A polynucleotide or multiple polynucleotides encoding a multi-specific antigen binding molecule that binds to human CD3 and an HIV antigen, wherein the antigen binding molecule comprises:

• (a) a first antigen binding domain that comprises a first heavy chain variable domain (VH) and a first light chain variable domain (VL), wherein the first antigen binding domain binds to CD3 and comprises a first VH-complementarity determining region (CDR) 1, a first VH-CDR2, a first VH-CDR3, a first VL-CDR1, a first VL-CDR2 and a first VL-CDR3 comprising the following amino acid sequences, respectively:
• (i) SEQ ID NOs:
• 1, 11, 8, 4, 9 and 10;
• or
• (ii) SEQ ID NOs:
• 1, 12, 8, 4, 9 and 10, wherein the first VH and the first VL comprise the amino acid sequences of SEQ ID NOs:
• 51 and 56, respectively, or comprise amino acid sequences that are at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identical to the amino acid sequences set forth, respectively:
• SEQ ID NOs:
• 51 and 56;
• and
• (b) the second antigen binding domain comprises one or more extracellular (EC) domains of CD4.