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US 2025/0059252 A1Published application
Immunosuppressive Antigen-Specific Chimeric Antigen Receptor Treg Cells for Prevention and/or Treatment of Autoimmune and Alloimmune Disorders
AssigneeThe University of Toledo
InventorsJuan C. Jaume, Shahnawaz Imam
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Abstract
Described herein are immunoresponsive cells which are useful for their preventive and therapeutic potential against autoimmune diseases and rejections of solid organ transplants.
Claims20
An immunoresponsive cell comprising:
- a chimeric antigen receptor (CAR) that binds to glutamic acid decarboxylase 65 kDA (GAD65), the CAR comprising:
- a) an intracellular signaling domain, and
- b) an extracellular polypeptide comprising an amino acid sequence that is a GAD65 MAb antigen binding domain;
- wherein the extracellular polypeptide comprises SEQ ID NO:
- 7 or SEQ ID NO:
- 8, or an amino acid sequence having at least 95% identity to SEQ ID NO:
- 7 or SEQ ID NO:
- 8.
5 more elements
An immunoresponsive cell comprising:
- a chimeric antigen receptor (CAR) that binds to glutamic acid decarboxylase 65 kDA (GAD65), the CAR comprising:
- a) an intracellular signaling domain, and
- b) an extracellular polypeptide comprising SEQ ID NO:
- 7 or SEQ ID NO:
- 8, or an amino acid sequence having at least 95% identity to SEQ ID NO:
- 7 or SEQ ID NO:
- 8;
- wherein the immunoresponsive cell is a regulatory T cell.
5 more elements
An immunoresponsive cell comprising:
- a chimeric antigen receptor (CAR) that binds to glutamic acid decarboxylase 65 kDA (GAD65), the CAR comprising:
- a) an intracellular signaling domain, and
- b) an extracellular polypeptide comprising SEQ ID NO:
- 7 or SEQ ID NO:
- 8, or an amino acid sequence having at least 95% identity to SEQ ID NO:
- 7 or SEQ ID NO:
- 8.
4 more elements
Dependencies are inferred from the claim text.