Interleukin-2 agents and uses thereof
AssigneeVisterra, Inc.
InventorsScott Moore Carlson, Gregory Babcock, Zachary Shriver, Boopathy Ramakrishnan
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Abstract
IL-2 agents that comprise IL-2 variants are disclosed as well as methods, compositions, and uses thereof. The IL-2 agents described herein can be used to treat and/or prevent various disorders and conditions.
Claims20
A nucleic acid encoding an interleukin-2 (IL-2) variant, wherein the IL-2 variant comprises an amino acid sequence having at least 95% sequence identity to SEQ ID NO:
- 1 and
- (i) an amino acid substitution H16L, H16N, or I92S, and
- (ii) amino acid substitutions V69A and Q74P.
A nucleic acid encoding an IL-2 variant, wherein the IL-2 variant comprises the amino acid sequence of SEQ ID NO:
- 5.
A nucleic acid encoding an IL-2 fusion protein, wherein the IL-2 fusion protein comprises the amino acid sequence of SEQ ID NO:
- 1008.
Dependencies are inferred from the claim text.