Protease inhibitors

A compound of general formula (1) or a salt thereof:

• wherein
• tail is C1-24alkyl, —O—C1-24alkyl, 5-20-membered (hetero)aryl, or 3-20-membered (hetero)cycloalkyl, wherein tail is optionally unsaturated, wherein tail is optionally substituted with halogen, C1-3 (halo)alkyl, or C1-3 (halo)alkoxyl;
• head is —H, -h1, —O-h1, —C(O)-h1, —C(O)—N(H)h1, —N(h2) h1, or head is -C1-24alkyl, —(NH)0-1-5-20-membered (hetero)aryl, or —(NH)0-1-3-20-membered (hetero)cycloalkyl, wherein head is optionally unsaturated, wherein head is optionally substituted with halogen, C1-3 (halo)alkyl, or C1-3 (halo)alkoxyl;
• h1 is —H, —OH, —S(O)0-2—OH, C1-8 (halo)alkyl, C1-8 (halo)alkoxyl, —S(O)0-2-C1-8 (halo)alkyl, 3-8-membered (hetero)cycloalkyl, —S(O)0-2-[3-8-membered (hetero)cycloalkyl], -C1-4alkyl-[3-8-membered (hetero)cycloalkyl], 5-6-membered (hetero)aryl, —S(O)0-2-[5-6-membered (hetero)aryl], or C1-4alkyl[5-6-membered (hetero)aryl], wherein h1 is optionally substituted with halogen, C1-3 (halo)alkyl, or C1-3 (halo)alkoxyl;
• h2 is —H, —OH, —S(O)0-2—OH, C1-8 (halo)alkyl, C1-8 (halo)alkoxyl, —S(O)0-2-C1-8 (halo)alkyl, 3-8-membered (hetero)cycloalkyl, —S(O)0-2-[3-8-membered (hetero)cycloalkyl], -C1-4alkyl-[3-8-membered (hetero)cycloalkyl], 5-6-membered (hetero)aryl, —S(O)0-2-[5-6-membered (hetero)aryl], or C1-4alkyl[5-6-membered (hetero)aryl], wherein h2 is optionally substituted with halogen, C1-3 (halo)alkyl, or C1-3 (halo)alkoxyl;
• AA1 is an amino acid residue that is connected to its neighbouring AAn via an amide bond to which it contributes a donor carboxylic acid, and that is connected to tail via an amide bond of a secondary amide to which it contributes a donor amine;
• AAn is for each instance independently an amino acid residue, wherein the carbonyl moiety in the residue adjacent to head can instead together with head be replaced by —B(OH)2 or a C1-6alkyl ester thereof, —P(O)(OH)2 or a C1-6alkyl ester thereof, —S(O)2-halogen, or 5-12 membered (hetero)aryl that is optionally substituted with halogen, C1-3 (halo)alkyl, or C1-3 (halo)alkoxy;
• m is 1, 2, 3, 4, or 5.