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US 2025/0059211 A1Published application
Organic zinc compound and production method for organic zinc compound
AssigneeSynCrest Inc.
InventorsPengyu XU, Shin YONEYAMA
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Abstract
An object of the present invention is to provide a novel organic zinc compound useful for the synthesis of special amino acids. Provided are an organic zinc compound and a method for producing an organic zinc compound.
Claims5
An organic zinc compound represented by formula (1):
- wherein
- X is a chlorine atom or a bromine atom,
- Prot is a protecting group selected from a 9-fluorenylmethyloxycarbonyl protecting group (Fmoc), a tert-butoxycarbonyl protecting group (Boc), an allyloxycarbonyl protecting group (Alloc), or a benzyloxycarbonyl protecting group (Cbz),
- R1 is a hydroxyl group or a protecting group for a carboxylic acid, and
- R2 is a hydrogen atom or an alkyl group,
- wherein
- when X is a chlorine atom, Prot is Fmoc, Boc, Alloc, or Cbz, and
- when X is a bromine atom, Prot is Fmoc, Alloc, or Cbz.
5 more elements
A method for producing an organic zinc compound represented by formula (1):
- wherein
- X is a chlorine atom or a bromine atom,
- Prot is a protecting group selected from a 9-fluorenylmethyloxycarbonyl protecting group (Fmoc), a tert-butoxycarbonyl protecting group (Boc), an allyloxycarbonyl protecting group (Alloc), or a benzyloxycarbonyl protecting group (Cbz),
- R1 is a hydroxyl group or a protecting group for a carboxylic acid, and
- R2 is a hydrogen atom or an alkyl group;
- the method comprising reacting a compound represented by the following formula (2):
- wherein
- X, Prot, R1, and R2 are as defined in formula (1),
- and zinc in an organic solvent in the presence of a halogen compound,
- wherein
- in formulas (1) and (2),
- when X is a chlorine atom, Prot is Fmoc, Boc, Alloc, or Cbz, and
- when X is a bromine atom, Prot is Fmoc, Alloc, or Cbz.
10 more elements
Dependencies are inferred from the claim text.