Heterocyclic Compounds and Methods of Use

A compound of Formula (I):

• or a pharmaceutically acceptable salt of said compound, wherein;
• is a single bond or a double bond;
• W is C, CH or N;
• n is 0, 1, 2, or 3;
• m is 0, 1, 2, 3 or 4;
• each Rx is hydroxyl, halogen, oxo, cyano, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, —T—Ry or two Rx taken together can form a bridged ring, wherein the bridge is selected from one of the following:
• —C1-4 alkylene, —O—C1-4 alkylene, —C1-4 alkylene-O—C1-4 alkylene- or —C1-4 alkylene-S—C1-4 alkylene-;
• Z is CH, CR′ or N;
• R′ is halogen, cyano or C1-4 alkyl;
• L is a bond, C1-6 alkylene, C1-6 alkenylene, —O—C1-6 alkylene, —S—C1-6 alkylene, NRz, O or S;
• R1 is hydroxyl, aryl, heteroaryl, C3-5 cycloalkyl or heterocycloalkyl optionally substituted with 0-3 occurrences of R5;
• R2 is hydrogen, hydroxyl, halogen, amino, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C2-4 alkenyl, C2-4 alkynyl, C3-8 cycloalkyl or cyano;
• R3 is aryl or heteroaryl optionally substituted with 0-4 occurrences of R6;
• R4 is hydrogen, hydroxyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C2-4 alkenyl, C2-4 alkynyl, C3-8 cycloalkyl or cyano;
• each R5 is halogen, hydroxyl, oxo, amino, C1-4 alkyl or —T—Ry;
• each R6 is halogen, hydroxyl, amino, cyano, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl or C3-7 cycloalkyl;
• R7 is hydrogen, halogen or C1-4 alkyl;
• T is C1-4 alkylene, —O—, —S— or —C1-4 alkylene-C(O)—;
• Ry is halogen, hydroxyl, cyano or amino;
• and
• Rz is hydrogen or C1-4 alkyl;
• wherein when W is N, is a single bond, m is 2, 3, or 4 and two Rx are taken together to form a bridged ring, wherein the bridge is selected from one of the following:
• —C1-4 alkylene, —C1-4 alkylene-O—C1-4 alkylene- or —C1-4 alkylene-S—C1-4 alkylene-.