Tricyclic derivative inhibitor, preparation method therefor, and application thereof

A compound represented by general formula (I), or a stereoisomer or pharmaceutically acceptable salt thereof:

• wherein:
• ring A is selected from cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl or heteroaryl can be optionally further substituted;
• ring B is selected from cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl or heteroaryl can be optionally further substituted;
• R1 is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, deuterated alkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, cycloalkoxy, heterocyclyl, aryl, heteroaryl, —CRcc═CRdd(CH2)nRaa, —CRcc═CRdd(CH2)nNRaaRbb, —CRcc═CRdd(CH2)nNReeC(O)Raa, —CRcc═CRdd(CH2)nNReeC(O)NRaaRbb, —O(CH2)nRcc, —OC(RaaRbb)n(CH2)mRcc, —NRee(CH2)nRcc, —(CH2)n—, —(CH2)nRcc, —(CH2)nORcc, —(CH2)nSRcc, —(CH2)nC(O)Rcc, —(CH2)nC(═NRee)Rcc, —(CH2)nC(O)ORcc, —(CH2)nS(O)mRcc, —(CH2)nNRaaRbb, —(CH2)nC(O)NRaaRbb, —(CH2)nNReeC(O)Rcc, —(CH2)nN═S(O)RccRee or —(CH2)nNReeS(O)mRcc, wherein the alkyl, alkenyl, alkynyl, deuterated alkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl can be optionally further substituted;
• preferably, R1 is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, cycloalkoxy, heterocyclyl, aryl, heteroaryl, —CRcc═CRdd(CH2)nRaa, —CRcc═CRdd(CH2)nNRaaRbb, —CRcc═CRdd(CH2)nNReeC(O)Raa, —CRcc═CRdd(CH2)nNReeC(O)NRaaRbb, —O(CH2)nRcc, —OC(RaaRbb)n(CH2)mRcc, —NRee(CH2)nRcc, —(CH2)n—, —(CH2)nRcc, —(CH2)nORcc, —(CH2)nSRcc, —(CH2)nC(O)Rcc, —(CH2)nC(═NRee)Rcc, —(CH2)nC(O)ORcc, —(CH2)nS(O)mRcc, —(CH2)nNRaaRbb, —(CH2)nC(O)NRaaRbb, —(CH2)nNReeC(O)Rcc or —(CH2)mNReeS(O)mRcc, wherein the alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl can be optionally further substituted,
• R2 is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, cycloalkoxy, heterocyclyl, aryl or heteroaryl, wherein the alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl can be optionally further substituted;
• R3 is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, cycloalkoxy, heterocyclyl, aryl or heteroaryl, wherein the alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl can be optionally further substituted;
• R4 is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, oxo, thio, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —CR33═CR44(CH2)pR11, —CR33═CR44(CH2)pNR11R22, —CR33═CR44(CH2)pNR55C(O)R11, —CR33═CR44(CH2)pNR55C(O)NR11R22, —O(CH2)pR33, —OC(R11R22)q(CH2)pR33, —NR55(CH2)pR33, —(CH2)p—, —(CH2)pR33, —(CH2)pOR33, —(CH2)pSR33, —(CH2)pC(O)R33, —(CH2)pC(═NR55)R33, —(CH2)pC(O)OR33, —(CH2)pS(O)qR33, —(CH2)pNR11R22, —(CH2)pC(O)NR11R22, —(CH2)pNR55C(O)R33 or —(CH2)pNR55S(O)qR33, wherein the alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl can be optionally further substituted,
• alternatively, any two adjacent or non-adjacent R4 and adjacent atoms are connected to form cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl or heteroaryl can be optionally further substituted;
• Raa and Rbb are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein the amino, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl can be optionally further substituted,
• alternatively, Raa and Rbb together with adjacent atoms form cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl and heteroaryl can be optionally further substituted;
• Rcc, Rdd and Ree are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein the amino, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl can be optionally further substituted;
• R11 and R22 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein the amino, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl optionally can be further substituted,
• alternatively, R11 and R22 together with adjacent atoms form cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl and heteroaryl optionally can be further substituted;
• R33, R44 and R55 are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein the amino, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl optionally can be further substituted;
• m is 0, 1, 2 or 3;
• n is 0, 1, 2 or 3;
• p is 0, 1, 2 or 3;
• q is 0, 1,2 or 3;
• x is 0, 1, 2, 3 or 4;
• and
• y is an integer from 0 to 6.