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US 2025/0058024 A1Published application
Injectable tough and viscoelastic bta hydrogel
AssigneesUniversiteit Maastricht, Academisch Ziekenhuis Maastricht
InventorsMatthew Brandon BAKER, Shahzad HAFEEZ, Lorenzo MORONI, Ana Agustina ALDANA
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Abstract
The invention describes benzene-1,3,5-tricarboxamide (BTA) based hydrogels. The hydrogels have purpose in tissue culturing for in vitro applications such as drug screening or in vivo applications such as transplantation. The hydrogels are particularly tough but still allow 3D printing and cell culturing. The invention further describes 3D printing of the hydrogels and uses of the hydrogels.
Claims17
A compound having the formula represented by formula (Ia):
- wherein:
- each 1, m, and n are individually an integer between 1 to 18;
- and
- R1, R2 and R3 are each individually selected from a polymer or a reactive group,
- wherein
- the polymer is represented by
- R4
- wherein
- represents
- polyester co-polymers, polysaccharides, polyacrylates, polyacrylamides, polyurethanes or co-polymers thereof, wherein m is an integer from 1 to 20000 and
- wherein R4 is a natural chain end or a reactive group, and
- wherein the polymer is selected such that the compound is water soluble or water dispersible;
- and
- wherein the reactive group is selected from the group consisting of:
- a C1-C36 linear or branched alkyl or alkenyl or alkynyl or cycloalkyl,
- azides, alkynes, amines, oximes, hydrazides, semicarbazides, aldehydes, strained triple bonds, epoxides, malimides, furans or substitutions thereof, preferably substitutions with a linear or branched alkyl group, acrylate or acrylamide or sulphides thereof, and
- wherein at least one of R1, R2 or R3 is a polymer.
14 more elements
A method for 3D printing a structure, the method comprising:
- a. printing a composition comprising a compound having the formula represented by formula (Ia):
- wherein:
- each 1, m, and n are individually an integer between 1 to 18;
- and
- R1, R2 and R3 are each individually selected from a polymer or a reactive group,
- wherein
- the polymer is represented by
- R4
- wherein
- represents,
- polyester co-polymers, polysaccharides, polyacrylates, polyacrylamides, polyurethanes or co-polymers thereof, wherein m is an integer from 1 to 20000 and
- wherein R4 is a natural chain end or a reactive group, and
- wherein the polymer is selected such that the compound is water soluble or water dispersible;
- and
- wherein the reactive group is selected from the group consisting of:
- a C1-C36 linear or branched alkyl or alkenyl or alkynyl or cycloalkyl,
- azides, alkynes, amines, oximes, hydrazides, semicarbazides, aldehydes, strained triple bonds, epoxides, malimides, furans or substitutions thereof, preferably substitutions with a linear or branched alkyl group, acrylate or acrylamide or sulfides thereof, and
- wherein at least one of R1, R2 or R3 is a reactive group.
15 more elements
Dependencies are inferred from the claim text.