Stabilised liquid vaccines of live viruses
AssigneeIntervet Inc.
InventorsEdwin KETS, Martin PIEST, Paul VERMEIJ
Life of this patent
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Abstract
The present invention relates to liquid vaccine composition comprising a live virus and a natural deep-eutectic solvent (NADES) as the carrier. The carrier additionally comprises an additive selected from methionine and (hydroxy) ectoine. The additive is able to reduce the loss of virus titre over time, upon storage in a NADES-based liquid vaccine composition having up to 50% w/w of water. Such compositions are less viscous which is favourable for the manufacture of the carrier, and the formulation and use of the liquid vaccine.
Claims11
A liquid vaccine composition comprising a live virus and a pharmaceutically acceptable carrier, the carrier being a natural deep-eutectic solvent (NADES), and the vaccine having a water activity of at most 0.8, characterised in that the liquid vaccine composition has a water amount of up to 50% w/w, and the vaccine also comprises an additive selected from methionine, ectoine, and hydroxyectoine.
Dependencies are inferred from the claim text.