Platform and method for determining critical transcription factors (tf) for tf-based human induced pluripotent stem cell (hipsc) differentiation
AssigneeGameto, Inc
InventorsPranam Deb CHATTERJEE, Christian KRAMME
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Abstract
A platform and method for determining critical transcription factors for TF-based hiPSC differentiation. The platform including: a transcriptomic dataset database; at least a processor; a memory communicatively connected to the processor, the memory containing instructions configuring the at least a processor to generate gene regulatory networks from transcriptomic datasets; determine a candidate transcription factor; analyze an impact of the candidate transcription factor in germline cell development; and output a set of critical transcription factors.
Claims21
A platform for determining critical transcription factors for TF-based hiPSC differentiation, the platform comprising:
- a transcriptomic dataset database;
- at least a processor;
- and
- a memory communicatively connected to the processor, the memory containing instructions configuring the at least a processor to:
- generate a plurality of gene regulatory networks from a plurality of transcriptomic datasets;
- determine a candidate transcription factor;
- analyze an impact of the candidate transcription factor in germline cell development;
- and
- output a set of critical transcription factors.
A method for determining critical transcription factors for TF-based hiPSC differentiation, the method comprising:
- curating, using a computing device, a transcriptomic dataset database;
- generating, using the computing device, gene regulatory networks from a plurality of transcriptomic datasets;
- determining, using the computing device, a candidate transcription factor;
- analyzing, using the computing device, an impact of the candidate transcription factor in germline cell development;
- and
- outputting, using the computing device, a set of critical transcription factors.
21-22. (canceled)
Dependencies are inferred from the claim text.